polymorphism | factor | odds ratio | pvalue | initial number | replication number | Population | age of cases | shorter lived allele | longer lived allele | study type | reference |
rs5491 | ICAM1 | — | 5e-66 | 5036 | — | American | 28-70 | TT, AT | AA | Genome-Wide Association Study | 22174011 |
rs9330200 | TUBB4B | — | 6e-53 | 5036 | — | American | 28-70 | AA, AT | TT | Genome-Wide Association Study | 22174011 |
rs2292664 | RIMBP2 | — | 1.4e-37 | 5036 | — | American | 28-70 | CC, CG | GG | Genome-Wide Association Study | 22174011 |
rs4420638 | APOE | 0.72 | 3.4e-36 | 7729 vs 16121 | 13060 vs 61156 | European | 90+ | — | — | GWAS | 24688116 |
rs4537545 | IL6R | — | 3e-18 | 308 | — | American, European, Ashkenazi Jewish | 75.7 | — | — | Candidate Region/Gene | 19249341 |
rs2075650 | APOE | 0.71 | 3.39e-17 | 403 vs 1670 | 4149 vs 7582 | Dutch | mean 94 | e4 | — | Genome-Wide Association Study | 21418511 |
rs2075650 | APOE | 0.53 | 4.44e-16 | 2202 vs 2164 | — | Caucasian | 100 | — | — | Meta-Analysis | 24244950 |
rs4420638 | APOC1 | 0.53 | 1.8e-10 | 763 vs 1085 | 754 vs 850 | German | Mean age 99.7 | G | — | Genome-Wide Association Study | 21740922 |
rs2075650 | TOMM40 | 2.07 | 2.36e-10 | 801 vs 914 | 253 vs 341 | Caucasian | Median age 104 | G | A | Genome-Wide Association Study | 22279548 |
HRAS1 LASS1 (CGT) | APOE | — | 1.06e-09 | 68 vs 68 | — | American | — | — | — | Candidate Region/Gene | 20569235 |
E2 / E3 / E4 | APOE | — | 1.2e-08 | 560 vs 560 | — | French | centenarians 100th year or beyond, mean age 103.1 | E4 | — | Candidate Region/Gene | 11280044 |
rs2149954 | — | 1.10 | 1.74e-08 | 7729 vs 16121 | 13060 vs 61156 | European | 90+ | — | — | GWAS | 24688116 |
DRD4 7R allele | DRD4 | — | 3.5e-08 | 310 vs 2909 | — | European | mean age 95.2 years | — | — | Candidate Region/Gene | 23283341 |
rs1528753 | — | — | 8.1e-08 | 1345 cohort + 1087 offspring | — | American | — | — | — | Genome-Wide Association Study | 17903295 |
rs4420638 | APOE | — | 9.6e-08 | 4445 total (each a part of sibship of 2-5 siblings) | — | Caucasian, European | 90 | — | — | Genome-Wide Association Study | 23286790 |
AAT M/Z/S | AAT | 0.18 | 1e-07 | 143 vs 255 vs 127 | — | Italian | Centenarians | M, S | Z | Candidate Region/Gene | 17048073 |
rs3129046 | — | 0.66 | 2.21e-07 | 763 vs 1085 | 754 vs 850 | German | Mean age 99.7 | — | — | Genome-Wide Association Study | 21740922 |
rs1610742 | — | 0.66 | 3.02e-07 | 763 vs 1085 | 754 vs 850 | German | Mean age 99.7 | — | — | Genome-Wide Association Study | 21740922 |
rs4936894 | VWA5A | 1.11 | 3.38e-07 | 5974 (RS), 3267 (CHS), 3136 (FHS), 4511 (ARIC), 3219 (AGES), 902 (inCHIANTI), 620 (BLSA), 1661 (HABC), 1717 (SHIP) | Whitehall II - 6000 (UK), English Longitudinal Study of Ageing (UK), Religious Order Study - 1100, Memory and Ageing Project | American | — | A | — | Genome-Wide Association Study | 21782286 |
HRAS1 LASS1 (CGT) | APOE | — | 6.91e-07 | 204 vs 251 | — | American | — | — | — | Candidate Region/Gene | 20569235 |
rs970048 | Intergenic | 1.77 | 7.17e-07 | 3746 vs 5912 | — | Dutch | Mean age 94 | — | G | Genome-Wide Association Study | 21418511 |
rs970048 | Intergenic | 1.77 | 7.17e-07 | 403 vs 1670 | 3746 vs 5912 | Dutch | Mean age 94 | — | G | Genome-Wide Association Study | 21418511 |
HFE C282Y | HFE | — | 7.2e-07 | 35 vs 106 | — | | 91-105 (< 50 versus >90) | C | Y | Candidate Region/Gene | 11857056 |
HRAS1 LASS1 (CGT) | APOE | — | 1e-06 | 79 vs 88 | — | American | — | — | — | Candidate Region/Gene | 20569235 |
rs10493513 | — | — | 1.5e-06 | 1345 cohort + 1087 offspring | — | American | — | — | — | Genome-Wide Association Study | 17903295 |