Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs429358, rs7412 APOE 0.43 0.0006 114 vs 2071 — Irish >90 e4 e2 Candidate Region/Gene 11470126
192 (Q/R) PON1 1.30 0.007 308 vs 579 Italian, 296 vs 296 Irish — Irish, Italian Italian 100.8 years, Irish 89.8 years Q — Candidate Region/Gene 15050299
192 PON1 1.26 0.007 Italian: 308 vs 579; Northern Irish: 296 vs 296 — Irish Italian: Mean age 100.8 +/- 2.1; Northern Irish: Mean age 89.8 +/- 5.7 Q — Candidate Region/Gene 15050299
2437 T>C HSPA1L — 0.01 129 vs 100 — Irish 80–97 2437C — Candidate Region/Gene 12742533
KIR2DS3 KIR2DS3 — 0.02 93 vs 100 89 vs 89 Irish 80-97 — — Candidate Region/Gene 15288696
KIR2DL5 KIR2DL5 — 0.03 93 vs 100 89 vs 89 Irish 80-97 — — Candidate Region/Gene 15288696
KIR2DS3 haplotypes KIR2DS3 — 0.05 100 vs 100 — Irish Age range: 65-99 — — Candidate Region/Gene 21299522
rs662 PON1 1.06 0.086 5086 vs 4269 — Irish >/=80 — — Candidate Region/Gene 20362697
mt9055A mtDNA — 0.164 129 vs 100 — Irish 80-97 — — Mitochondrial Haplogroup 11404057
rs662 PON1 1.06 0.33 — — Irish >/=80 — — Candidate Region/Gene 20362697
55 (L/M) PON1 0.94 0.44 308 vs 579 Italian, 296 vs 296 Irish — Irish, Italian Italian 100.8 years, Irish 89.8 years — — Candidate Region/Gene 15050299
rs662 PON1 1.03 0.55 — — Irish >/=100 — — Candidate Region/Gene 20362697
(HLA)-A1, B8, DR3 — — 1.0 93 vs 100 — Irish 80-97 years — — Candidate Region/Gene 12714268
rs1800629 TNF — 1.0 93 vs 100 — Irish 80-97 years — — Candidate Region/Gene 12714268
rs909253 TNF — 1.0 93 vs 100 — Irish 80-97 years — — Candidate Region/Gene 12714268
rs72533289 KIR2DS4 — 1.0 180 vs 180 — Irish Mean age 89 — — Candidate Region/Gene 15130674
  • 16 variants