Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs4420638 APOE 0.72 3.4e-36 7729 vs 16121 13060 vs 61156 European 90+ — — GWAS 24688116
rs4537545 IL6R — 3e-18 308 — American, European, Ashkenazi Jewish 75.7 — — Candidate Region/Gene 19249341
rs2149954 — 1.10 1.74e-08 7729 vs 16121 13060 vs 61156 European 90+ — — GWAS 24688116
DRD4 7R allele DRD4 — 3.5e-08 310 vs 2909 — European mean age 95.2 years — — Candidate Region/Gene 23283341
rs4420638 APOE — 9.6e-08 4445 total (each a part of sibship of 2-5 siblings) — Caucasian, European 90 — — Genome-Wide Association Study 23286790
rs7896005 SIRT1 2.38 0.003 224 vs 293 170 vs 220 Caucasian, European 90-103, 98+ (replication) G — Candidate Region/Gene 21972126
- Insulin signaling pathway (IIS) — 0.01 403 vs 1670 — European 90-103 — — Genome-Wide Association Study 22113349
- Telomere maintenance pathway (TM) — 0.02 403 vs 1670 — European 90-103 — — Genome-Wide Association Study 22113349
marker D4S1564 — — 0.044 308 — European min. age 98 for one sibling. 91+ males, 95+ females — — Genome-Wide Association Study 11526246
rs132793 XRCC6 — 0.74 224 vs 293 170 vs 220 Caucasian, European 90-103, 98+ (replication) — — Candidate Region/Gene 21972126
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