| polymorphism | factor | odds ratio | pvalue | initial number | replication number | Population | age of cases | shorter lived allele | longer lived allele | study type | reference |
| rs4537545 | IL6R | — | 3e-18 | 308 | — | American, European, Ashkenazi Jewish | 75.7 | — | — | Candidate Region/Gene | 19249341 |
| HRAS1 LASS1 (CGT) | APOE | — | 1.06e-09 | 68 vs 68 | — | American | — | — | — | Candidate Region/Gene | 20569235 |
| E2 / E3 / E4 | APOE | — | 1.2e-08 | 560 vs 560 | — | French | centenarians 100th year or beyond, mean age 103.1 | E4 | — | Candidate Region/Gene | 11280044 |
| DRD4 7R allele | DRD4 | — | 3.5e-08 | 310 vs 2909 | — | European | mean age 95.2 years | — | — | Candidate Region/Gene | 23283341 |
| AAT M/Z/S | AAT | 0.18 | 1e-07 | 143 vs 255 vs 127 | — | Italian | Centenarians | M, S | Z | Candidate Region/Gene | 17048073 |
| HRAS1 LASS1 (CGT) | APOE | — | 6.91e-07 | 204 vs 251 | — | American | — | — | — | Candidate Region/Gene | 20569235 |
| HFE C282Y | HFE | — | 7.2e-07 | 35 vs 106 | — | | 91-105 (< 50 versus >90) | C | Y | Candidate Region/Gene | 11857056 |
| HRAS1 LASS1 (CGT) | APOE | — | 1e-06 | 79 vs 88 | — | American | — | — | — | Candidate Region/Gene | 20569235 |
| HRAS1 LASS1 (CGT) | APOE | — | 9e-06 | 19 vs 73 | — | Georgian | — | — | — | Candidate Region/Gene | 20569235 |
| HRAS1 LASS1 (CCT) | APOE | — | 1e-05 | 128 vs 115 | — | Georgian | — | — | — | Candidate Region/Gene | 20569235 |
| rs507879 | CASP5 | — | 1.4e-05 | 510 vs 549 | — | Russian | 75–103 | AG | AA, GG | Candidate Region/Gene | 20434535 |
| rs4946936 | FOXO3 | 1.40 | 1.8e-05 | 761 vs 1056 | 350 vs 350 | Chinese | mean age 102.3 | T | C | Candidate Region/Gene | 19793722 |
| rs1042718-rs1042719 | ADRB2 | 0.63 | 1.86e-05 | 384 vs 384 | 579 vs 644 | Chinese | Mean age 102.1±0.20 | G-C | A-C | Candidate Region/Gene | 23020224 |
| rs915179-rs2485662-rs4641-rs1468772 | LMNA | 1.56 | 2.5e-05 | 873 vs 443 | New England Centenarian Study (NECS) (N = 738), (ii) the Southern Italian Centenarian Study (SICS) (N = 905), (iii) France (N = 1103), and (iv) the Einstein Ashkenazi Longevity Study (N = 702) | American, Caucasian | Mean age 101.5 | — | GTCT | Candidate Region/Gene | 22340368 |
| rs2802292 | FOXO3 | 1.36 | 2.9e-05 | 761 vs 1056 | 350 vs 350 | Chinese | mean age 102.3 | G | T | Candidate Region/Gene | 19793722 |
| HRAS1 LASS1 (CCT) | APOE | — | 4.1e-05 | 147 vs 188 | — | Georgian | — | — | — | Candidate Region/Gene | 20569235 |
| rs2755213 | FOXO1 | 0.75 | 7.4e-05 | 761 vs 1056 | 350 vs 350 | Chinese | mean age 102.3 | C | T | Candidate Region/Gene | 19793722 |
| HRAS1 LASS1 (CGT) | APOE | — | 7.8e-05 | 147 vs 188 | — | Georgian | — | — | — | Candidate Region/Gene | 20569235 |
| rs2253310 | FOXO3 | 1.35 | 7.9e-05 | 761 vs 1056 | 350 vs 350 | Chinese | mean age 102.3 | C | G | Candidate Region/Gene | 19793722 |
| VNTR in intron 5 (DeltaEF1 site) | SIRT3 | — | 8e-05 | 242 vs 703 | — | Italian | Median age 102 | 2b | — | Candidate Region/Gene | 15676284 |
| HRAS1 LASS1 (CCT) | APOE | — | 9.5e-05 | 204 vs 251 | — | American | — | — | — | Candidate Region/Gene | 20569235 |
| rs2542052 | APOC3 | — | 0.0001 | 213 old vs 216 offspring vs 258 controls | — | Ashkenazi Jewish | 100+ | A | — | Candidate Region/Gene | 16602826 |
| AAT M/Z/S | AAT | 0.21 | 0.0001 | 143 vs 255 | — | | Minimum age 99 | M, S | — | Candidate Region/Gene | 17048073 |
| rs12050077 | TSHR | 1.68 | 0.0001 | 232 vs 163 | — | Ashkenazi Jewish | Median age 97 | G | A | Candidate Region/Gene | 19837933 |
| rs1207362 | KL | 0.63 | 0.0001 | 1089 vs 736 | 1613 vs 1104 | Danish | 92-93 years old | A | C | Candidate Region/Gene | 22406557 |
