Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs2075650 APOE 0.53 4.44e-16 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
rs2075650 TOMM40 2.07 2.36e-10 801 vs 914 253 vs 341 Caucasian Median age 104 G A Genome-Wide Association Study 22279548
rs4420638 APOE — 9.6e-08 4445 total (each a part of sibship of 2-5 siblings) — Caucasian, European 90 — — Genome-Wide Association Study 23286790
rs12629971 EIF4E3 1.61 1.9e-06 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
rs1322048 TEK 1.27 2.94e-06 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
rs1456669 Intergenic 1.58 4.05e-06 801 vs 914 — Caucasian Median age 104 C A Genome-Wide Association Study 22279548
rs1525501 — 0.72 4.94e-06 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
rs4977756 Intergenic 1.37 7.97e-06 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
rs6801173 EIF4E3 1.52 8.16e-06 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
rs4802234 CEACAM16 1.36 9.22e-06 801 vs 914 — Caucasian Median age 104 A C Genome-Wide Association Study 22279548
rs9899404 GIP 1.30 1.09e-05 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
rs4073968 Intergenic 1.38 1.24e-05 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
rs997675 Intergenic 1.24 1.41e-05 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
rs1063192 CDKN2A 1.35 1.66e-05 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
rs4722094 Intergenic 1.41 1.93e-05 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
rs915179 LMNA 1.34 2.3666e-05 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
rs915179-rs2485662-rs4641-rs1468772 LMNA 1.56 2.5e-05 873 vs 443 New England Centenarian Study (NECS) (N = 738), (ii) the Southern Italian Centenarian Study (SICS) (N = 905), (iii) France (N = 1103), and (iv) the Einstein Ashkenazi Longevity Study (N = 702) American, Caucasian Mean age 101.5 — GTCT Candidate Region/Gene 22340368
rs4285687 Intergenic 1.21 2.58e-05 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
rs3803833 — 0.77 2.72e-05 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
rs1016013 — 1.21 2.87e-05 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
rs2758331 SOD2 1.33 2.92563e-05 801 vs 914 — Caucasian Median age 104 C A Genome-Wide Association Study 22279548
rs2247549 Intergenic 1.69 3.2e-05 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
rs2738173 DEFB1 1.41 3.46e-05 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
rs1016013 Intergenic 1.30 3.61e-05 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
rs147295 ELL2 1.16 3.67e-05 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
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  • 25 of 388 variants