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Longevity DB
Genetic variants implicated in human longevity.
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African European
Australian
Canadian
English People
Finn
Georgian
Human
Israeli
Multiethnic
Pomeranian
Sichuan
Spanish
Terraner
Age, Gene/Environment Susceptibility -Reykjavik Study Cohort (Island)
American
African American
American (Caucasian)
Amish
Atherosclerosis Risk Communities Study Cohort
Baltimore Longitudinal Study of Ageing Cohort
Cardiovascular Health Study Cohort
Caucasians (USA)
CHS (USA)
Framingham Heart Study Cohort
Framingham Heart Offspring Study Cohort
Gaucha population (Native South American)
Gerorgia (US)
New England American
North American
Mexican
Mexican Mestizo (see notes)
Study of Osteoporotic Fractures Cohort
The Health, Aging and Body Composition (USA)
US North European
USA (Black and European)
USA (Casucasians)
USA (Framington Heart Study)
Arab
Israelis
Nigerian
Tunisian
Turkish
Asian
Chinese
Bama Chinese
Chuang Chinese
Dujiangyan Han Chinese
Guangxi Bama Chinese
Han
Kahzak
Northern Chinese
Shanghai Chinese
Shenyang Chinese
Southern Chinese
Uyghur
Xinjiang Hetian Uyghur
Zhuang
Bama Zhuang
Japanese
Okinawan
Tokyo Japanese
Korean
Australian (Caucasian)
Australian centenarians of Caucasian ancestry
Brazilian
Gaucha Brazilian
Caucasian
Caucasian (NECS cohort)
Caucasian north
mostly Caucasian
European
African/European
British
English
Central European
Polish
Croatian
Danish
Dutch
Leiden Population
Rotterdam Population
Eastern European
European and Caucasian (many different european countries)
European Caucasian (Portuguese
European-origin (Caucasian)
French
German
Study of Health in Pomerania (Germany)
Greek
Irish
Belfast Irish
Northern Irish
Italian
Calabrian
Central Italian
Continental Italian
Invecchiare nel Chianti Cohort
Northeastern Italian
Northern Italian
Lombardy region Northern Italian
Northerncentral Italian
Sardinian
Southern Italian
Apulian
Calabrian
Northern European
Finns
Southern Finns
Tampere Population
Scottish
Southeastern Europe
Bulgarian
Southern European
Swiss
Western European
Spaniard
Caucasian Spanish
Caucasians from the city of Lleida in northeast Spain
Northern Spaniard
Spanish Combined: Pyrenees and Ebro’s Valley
Swedish
White European
Female
Caucasian Women
Georgia
Hispanic
Jewish
Ashkenazi Jewish
European-American Ashkenazi Jewish
Jordanian
Louisiana
Male
Mixed
Mixed Non-Hisp White
Slavs
Soviet
Russian
St. Petersburg Russian
Tatar
Tartarish
Population:
+
-
Finn «
Study type:
+
-
Candidate Region/Gene (14)
Mitochondrial Haplogroup (1)
Variant type:
+
-
SNP (8)
Locus (1)
Haplotype (3)
STR (1)
Variant effect:
+
-
Longevity‑Associated (7)
No Age Effect (8)
polymorphism
factor
odds ratio
pvalue
initial number
replication number
Population
age of cases
shorter lived allele
longer lived allele
study type
reference
APOE polymorphism
APOE
—
0.0001
291 vs 589
—
Finn
Mean age 97.5
e4
e2
Candidate Region/Gene
16487435
APOE haplotype - rs1346044
APOE
—
0.0001
175 vs 178
—
Finn
100.8
e4
e2
Candidate Region/Gene
10069711
rs429358, rs7412
APOE
—
0.001
179 vs 615
—
Finn
Mean age 100
e4
e2, e3
Candidate Region/Gene
8018664
Mitochondrial haplogroups
mtDNA
—
0.001
225 (cases) vs 400 middle aged vs 257 infants
—
Finn
90-91
H
U, J, K
Mitochondrial Haplogroup
12483296
rs1061170
CFH
1.78
0.005
491 with follow-up during 4 years
—
Finn
>90
—
TT
Candidate Region/Gene
19000922
rs1061170
CFH
1.78
0.005
491 vs 0
—
Finn
—
His
—
—
19000922
rs1800795
IL-6
—
0.018
285
—
Finn
90-95
C
G
Candidate Region/Gene
15664628
APOE e2/e3/e4
APOE
4.40
0.02
179
—
Finn
Minimum age 104
e3, e4
e2
Candidate Region/Gene
11213279
APOE e2,e3,e4
APOE
—
0.05
185 vs 486
—
Finn
Over 100
E4
e2
Candidate Region/Gene
8018664
rs16944
IL1B
—
0.08
250 vs 400
—
Finn
>90
—
—
Candidate Region/Gene
11640949
intron 2 VNTR
IL1RN
—
0.08
250 vs 400
—
Finn
>90
—
—
Candidate Region/Gene
11640949
rs1800795
IL6
—
0.23
250 vs 400
—
Finn
>90
—
—
Candidate Region/Gene
11640949
rs1800587
IL1A
—
0.31
250 vs 400
—
Finn
>90
—
—
Candidate Region/Gene
11640949
rs1143634
IL1B
—
0.53
250 vs 400
—
Finn
>90
—
—
Candidate Region/Gene
11640949
rs1800896
IL10
—
0.64
250 vs 400
—
Finn
>90
—
—
Candidate Region/Gene
11640949
rs1800629
TNF
—
0.76
250 vs 400
—
Finn
>90
—
—
Candidate Region/Gene
11640949
16 variants
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