YPC1 deletion | Deletion of YPC1 decreases replicative lifespan by 15% in the alpha strain [19030232]. | Yeast | -15 | — | — |
YPK1 deletion | Deletion of YPK1 decreases replicative lifespan by 20% in the alpha strain [18340043]. | Yeast | -20 | — | — |
YVH1 deletion | Deletion of YVH1 increases replicative lifespan by 50% in the alpha strain [18340043]. | Yeast | +50 | — | — |
Resveratrol supplementation | Resveratrol significantly extends the lifespan [12939617]. | Yeast | — | — | — |
OSH3 overexpression | Overexpression of OSH3 with the promoter of VAC8 shortens mean replicative lifespan ad promotes vacuolar fusion [Xia et al. unpublished]. | Yeast | — | — | — |
OSH3 deletion | Mean replicative lifespan of OSH3 deletion mutant is not significant different from wild type [Fusheng, unpublished]. | Yeast | — | — | — |
OSH6 mutation | The CC domain of Osh6 is dispensable for longevity. Deletion of the CC domain leads Osh6 to the late endosome [Fusheng Tang, personal communication]. | Yeast | — | — | — |
OSH7 mutation | Deletion of the CC domain of Osh7 ((Perg6-OSH7-ORD) greatly shortens the lifespan [Tang et al., personal communication]. | Yeast | — | — | — |
PEP4 overexpression | — | Yeast | — | — | — |
GAD1 deletion | GAD1 deletion extends replicative lifespan [21371425]. | Yeast | — | — | — |
UGA4 deletion | Deletion of UGA4 does not effect replicative lifespan [21371425]. | Yeast | — | — | — |
CTF8 deletion | Deletion of CTF8 increases mean chronological lifespan by 15-92% (15, 18, 42, 45, 92) in diploid cells [21447998]. | Yeast | +15 to +92 | — | — |
BMH2 overexpression | Overexpressing 14-3-3 protein, Bmh2, significantly extends median chronological lifespan by activating stress response [19805817]. | Yeast | — | — | — |
LEU3 deletion | LEU3 deletion dramatically increases chronological lifespan [19302372]. | Yeast | — | — | — |
YSC84 deletion | Deletion of YSC84 increases replicative lifespan by 20% in the alpha strain [19030232]. YSC84 deletion increases replicative lifespan by 25% in the alpha strain [18340043]. | Yeast | +20 to +25 | — | — |
YPT6 deletion | Deletion of YPT6 increases replicative lifespan by 20% [19030232]. YPT6 deletion increases replicative lifespan by 30% in the alpha strain and by 10% in the a strain [18340043]. | Yeast | +10 to +30 | — | — |
YME1 deletion | Deletion of YME1 decreases chronological lifespan by 50% [17492370] as well as replicative lifespan by 45% in the alpha strain [18340043]. | Yeast | -45 to -50 | — | — |
YDC1 overexpression | YDC1 overexpression decreases chronological lifespan by 40% [19059240]. | Yeast | -40 | — | — |
VHS1 deletion | Deletion of VHS1 increases replicative lifespan [16293764]. VHS1 deletion increases replicative lifespan by 60% in the alpha strain [19030232]. | Yeast | +60 | — | — |
VAM3 deletion | Deletion of VAM3 decreases mean replicative lifespan by 56% both on AL [19030232] and on moderate DR [18690010] (in BY4742/alpha strain). | Yeast | -56 | — | — |
TMA19 deletion | Deletion of TMA19 increases median replicative lifespan by 16% (P<0.02) [16806052]. TMA19 deletion increases mean replicative lifespan by 25-30% in the alpha and a strains [19030232]. | Yeast | +25 to +30 | +16 | — |
TIF4631 deletion | Deletion of TIF4631 increases replicative lifespan by 20% in the alpha and a strains [18340043].
TIF4631 increases replicative lifespan by 10-20% in the alpha and a strains [19030232]. | Yeast | +10 to 20 | — | — |
TIF1 deletion | Deletion of TIF1 increases replicative lifespan by 20% in the alpha strain [19030232]. TIF1 deletion increases by 30% in the alpha strain and 15% in the a strain [18340043]. | Yeast | +15 to +30 | — | — |
SWF1 deletion | Deletion of SWF1 decreases replicative lifespan by 30% in the alpha strain [19030232; 18340043]. | Yeast | -30 | — | — |
RPS6B deletion | RPS6B deletion increases mean replicative lifespan by about 30% [16293764]. Deletion of RPS6B, but not of the RPS6A paralog increases replicative median lifespan robustly by 45% [17174052]. | Yeast | +30 | +45 | — |