Experiments
Lifespan experiments.
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Study: Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks.
Species: Nematode
Data: network rnai_treatment symbol mean_extension function
WLN T23D8.3 T23D8.3 25.7 Translation
WLN F37C12.9 rps-14 16.6 Translation
WLN T09A5.10 lin-5 16.4 Cell division
WLN/HLN C03C10.3 rnr-2 14.2 DNA biosynthesis
HLN R02D3.3 R02D3.3 13.0 RNA polymerase II
WLN F54E7.2 rps-12 11.6 Translation
HLN F10B5.6 emb-27 10.5 Cell division
WLN F09F7.3 F09F7.3 8.1 RNA polymerase III
HLN F29G9.3 aps-1 7.9 Adaptin
HLN T09B4.10 chn-1 7.1 Ubiquitin ligase
WLN C38D4.3 mel-28 6.5 Cell division
WLN T20B12.8 hmg-4 6.5 Transcription elongation
WLN F35G12.10 asb-1 6.4 ATP synthase
WLN/HLN F26F4.11 rpb-8 6.4 RNA polymerase II
HLN F28D9.1 rsr-1 6.1 Splicing
WLN ZK1067.1 let-23 5.6 EGF receptor
WLN C47D12.2 C47D12.2 5.5 Unknown
WLN K10B3.7 gpd-3 5.3 Glycolysis
HLN F18A1.5 rpa-1 5.1 DNA replication
HLN C01H6.5 nhr-23 4.9 Molting
HLN F31D4.3 fkb-6 2.4 Immunophilin
WLN F43E2.7 F43E2.7 2.4 Mitochondrial carrier protein
n/a Control n/a 0 n/a
WLN R144.2 R144.2 -18.9 mRNA cleavage and polyadenylation
WLN K07D4.3 rpn-11 -19.3 Proteasome
WLN B0285.1 B0285.1 -22.2 Kinase
HLN Y40B1A.4 sptf-3 -22.9 Transcription factor
WLN R13G10.1 dpy-27 -23.5 Condensin
WLN W07B3.2 gei-4 -27.0 Filament regulation
HLN ZK1058.2 pat-3 -28.1 Integrin
HLN C52E4.4 rpt-1 -28.4 Proteasome
HLN F26H9.6 rab-5 -38.0 Endocytosis
HLN D1014.3 snap-1 -39.9 Vesicle fusion
HLN K02D10.5 K02D10.5 -48.6 SNARE complex
#Postdevelopmental inactivation of 377 first-order LAG interactors in the WLN and HLN identified
#104 candidates that conferred an increase in survival, and 55 a decrease. To subject candidates
#to a more rigorous assessment of lifespan, 60 candidates (48 long-lived and 12 short-lived)
#were inactivated postdevelopmentally in an enhanced RNAi mutant, eri-1. Survival was scored
#on alternate days and significance was determined by Kaplan-Meier analysis with a threshold of
#p<0.05. Our analysis confirmed the phenotypes of 33 new regulators of longevity, 22 that
#increase longevity and 11 that shorten it, listed here with their network association (worm or
#human longevity network), gene identifications, percentage change mean lifespan in
#comparison to an empty vector RNAi control, and functional annotations. Annotations suggest
#that these genes contribute to diverse biological functions, such as translation and energy
#metabolism, disruption of which is strongly associated with longevity extension and endocytosis,
#which has been identified as a requirement for lifespan extension downstream of insulin/IGF-1
#signaling.
Study: C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress.
Species: Nematode
Data: genotype mean max
wt 21 30
sir-2.4(OE) 21 30
Study: C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress.
Species: Nematode
Data: genotype treatment mean max
N2 control 15 31
N2 sir-2.4(RNAi) 20 31
daf-2 control 52 93
daf-2 sir-2.4(RNAi) 52 89
Study: Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles.
Species: Fruit fly
Data: Genotype;Gender;num;Mean;SD;Max;pvalue
#separator=;
#temperature=25
Canton-S;Male;264;46.85;12.33;68
dor;Male;295;8.96;3.73;20;<0.0001
dor;Female;98;10.07;3.62;15;<0.0001
dor;Male;106;13.94;2.95;19;<0.0001
hook/hook;Male;110;18.76;8.27;58;<0.0001
hook;Male;338;19.861;7.26;36;<0.0001
carnation;Male;242;17.42;8.69;48;<0.0001
bchs/df clot;Male;330;21.69;10.54;46;<0.0001
bchs/bchs;Male;274;23.7;6.9;37;<0.0001
carmine;Male;351;21.97;6.96;38;<0.0001
light;Male;247;24.92;8.8;61;<0.0001
garnet;Male;111;27.41;11.75;45;<0.0001
ruby;Male;183;31.57;8.842;53;0.0001
atg8aep362;Male;150;41.9;15.4;66;0.0040
Study: Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles.
Species: Fruit fly
Data: Genotype;Gender;num;Mean;SD;Max;pvalue
#separator=;
#temperature=29
white1118;Male;124;36.02;10.97;58
deep orange;Male;136;8.19;2.4;14;<0.0001
rosy;Male;128;19.8;5.98;38;<0.0001
carmine;Male;122;20.69;7.73;36;<0.0001
carnation;Male;121;23.868;8.78;42;<0.0001
bchs/bchs;Male;156;20.08;6.74;36;<0.0001
bchs/Df(2L)clot7;Male;80;22.23;6.3;32;<0.0001
bchs (EP2299);Male;196;25.87;9.09;44;<0.0001
atg8a;Male;153;27.16;7.732;45;<0.0001
garnet;Male;98;32.08;13.84;54;0.0194
Study: Overexpression of Fatty-Acid-β-Oxidation-Related Genes Extends the Lifespan of Drosophila melanogaster.
Species: Fruit fly
Data: genotype diet mean median max gender
#background=white1118
da/+ - 26 32 64 male
EPCG6783/+ - 46 - 70 male
da>EPCG6783 - 46 58 72 male
EPCG13890/+ - 32 - 56 male
da>EPCG13890 - 35 42 60 male
Act-GS-Gal4>UAS-CG6783 RU- 31 - 65 female
Act-GS-Gal4>UAS-CG6783 RU+ 34 - 58 female
Study: Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks.
Species: Nematode
Data: intervention;symbol;mean_extension;max_extension;function;extra
#separator=;
#background=N2 Bristol
T23D8.3(RNAi);T23D8.3;25.7;34.7;Translation;
F37C12.9(RNAi);rps-14;16.6;21.7;Translation;
T09A5.10(RNAi);lin-5;16.4;8.7;Cell division;
C03C10.3(RNAi);rnr-2;14.2;21.7;DNA biosynthesis;b
F54E7.2(RNAi);rps-12;11.6;21.7;Translation;
F09F7.3(RNAi);F09F7.3;8.1;21.7;RNA polymerase III;
C38D4.3(RNAi);mel-28;6.5;8.7;Cell division;
T20B12.8(RNAi);hmg-4;6.5;0.0;Transcription elongation;
F35G12.10(RNAi);asb-1;6.4;0.0;ATP synthase;
F26F4.11(RNAi);rpb-8;6.4;0.0;RNA polymerase II;b
C47D12.2(RNAi);C47D12.2;5.5;8.7;Unknown;
K10B3.7(RNAi);gpd-3;5.3;0.0;Glycolysis;
R144.2(RNAi);R144.2;-18.9;-25.0;mRNA cleavage and polyadenylation;
K07D4.3(RNAi);rpn-11;-19.3;-25.0;Proteasome;
B0285.1(RNAi);B0285.1;-22.2;-25.0;Kinase;
R13G10.1(RNAi);dpy-27;-23.5;-25.0;Condensin;
W07B3.2(RNAi);gei-4;-27.0;-38.0;Filament regulation;
# %D mean and %D maximum lifespan (last quartile) were calculated in relation # to control.
# Shared genes in WLN and HLN.
# doi:10.1371/journal.pone.0048282.t001
Study: Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks.
Species: Nematode
Data: intervention;symbol;mean_extension;max_extension;function;extra
#separator=;
#background=N2 Bristol
C03C10.3(RNAi);rnr-2;14.2;21.7;DNA biosynthesis;b
R02D3.3(RNAi);R02D3.3;13.0;21.7;RNA polymerase II;
F10B5.6(RNAi);emb-27;10.5;8.7;Cell division;
F29G9.3(RNAi);aps-1;7.9;0.0;Adaptin;
T09B4.10(RNAi);chn-1;7.1;8.7;Ubiquitin ligase;
F26F4.11(RNAi);rpb-8;6.4;0.0;RNA polymerase II;b
F28D9.1(RNAi);rsr-1;6.1;0.0;Splicing;
F18A1.5(RNAi);rpa-1;5.1;21.7;DNA replication;
C01H6.5(RNAi);nhr-23;4.9;8.7;Molting;
Y40B1A.4(RNAi);sptf-3;-22.9;-37.0;Transcription factor;
ZK1058.2(RNAi);pat-3;-28.1;-50.0;Integrin;
C52E4.4(RNAi);rpt-1;-28.4;-50.0;Proteasome;
F26H9.6(RNAi);rab-5;-38.0;-50.0;Endocytosis;
D1014.3(RNAi);snap-1;-39.9;-50.0;Vesicle fusion;
K02D10.5(RNAi);K02D10.5;-48.6;-72.0;SNARE complex;
# %D mean and %D maximum lifespan (last quartile) were calculated in relation to # control.
# Shared genes in WLN and HLN.
# doi:10.1371/journal.pone.0048282.t002
Study: Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging.
Species: Budding yeast
Data: genotype mean median max num pvalue pvalue pvalue
#temperature=30
wt 23.2 24 38 40 - - -
afg3 28.4 28 56 160 2.04E-03 - -
hac1 25.6 26 40 20 3.22E-01 2.15E-0.1 -
afg3;hac1 30.7 32 50 40 2.08E-04 1.16E-01 3.49E-02
# Note: afg3;hac1 max LS is guessed.
Study: Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging.
Species: Budding yeast
Data: genotype treatment mean median max num pvalue pvalue pvalue
#temperature=30
fob1 - 32.7 35 52 39 - - -
afg3;fob1 - 38.3 40 60 40 2.29E-02 - -
wt - 20.3 19 38 80 - - -
afg3 - 25.5 24 60 180 1.15E-03 - -
sir2;fob1 - 19.7 20 40 39 9.29E-01 1.25E-02 -
sir2;fob1;afg3 - 29.1 30 45 40 1.43E-06 1.42E-02 2.95E-05
sir2;fob1 - 30.8 34 46 20
sir2;fob1;afg3 - 46.0 44 78 20 3.60E-02 - -
sir2;fob1 DR 42.9 50 64 20 1.67E-02 9.14E-01 -
sir2;fob1;afg3 DR 45.3 48 67 20 1.48E-03 8.82E-01 7.56E-01
wt - 21.2 20 38 98 - - -
afg3 - 26.7 26 53 260 2.95E-07 - -
gcn4 - 22.7 21 42 80 2.24E-01 8.08E-04 -
afg3;gcn4 - 18.0 17 50 119 4.10E-03 7.59E-13 4.82E-04
wt - 19.8 19 33 39
afg3 - 24.2 24 45 100 4.77E-03 - -
rpl20b - 33.8 36 60 59 1.41E-08 4.34E-08 -
afg3rpl20b - 30.3 32 52 40 2.23E-05 1.70E-03 1.24E-01
Study: Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging.
Species: Budding yeast
Data: genotype mean median max num pvalue
#temperature=30
wt 24.4 22 55 125 -
sod1 3.8 3 16 76 6.71E-32
wt 26.3 25 48 45 -
ctt1 24.9 24 47 43 6.64E-01
wt 28.3 29 46 55 -
cta1 29.0 27 54 45 7.68E-01
wt 26.2 26 42 600 -
msn2;msn4 29.3 30 57 623 1.76E-08
wt 26.5 26 56 545
hac1 29.1 29 57 543 6.77E-06
wt 24.2 23 51 150
rad52 10.8 33 10 130
# Note for some strain MLS had to be guessed.
Study: Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging.
Species: Budding yeast
Data: genotype mean median max num pvalue
#temperature=30
wt 26.3 26 59 425 -
idh1 32.6 33 60 304 1.66E-14
wt 26.6 26 52 764 -
idh2 30.7 31 60 595 4.10E-11
wt 25.2 23 43 35
atp5 27.3 27 53 55 4.22E-01
wt 25.3 21 40 15 -
coq5 14.3 15 30 15 8.41E-04
Study: Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging.
Species: Budding yeast
Data: genotype mean median max pvalue pvalue pvalue
#temperature=30
wt 23.7 23 60 80 - - -
mrpl23 28.2 28 51 60 6.82E-03 - -
wt 25.8 24 53 60 - - -
yta12 20.0 20 41 53 5.45E-03 - -
wt 26.7 26 57 160 - - -
rho0 26.1 26 50 160 9.41E-01 - -
afg3 30.7 31 43 20 3.71E-02 5.25E-02 -
afg3;rho0 30.3 32 59 40 3.00E-02 7.74E-02 9.94E-01
W303 18.8 20 36 40 - - -
W303;afg3 19.6 21 36 80 6.87E-01 - -
# MLS of rho0 and some other are guessed.
Study: Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging.
Species: Budding yeast
Data: genotype mean median max num pvalue
#temperature=15
wt 22.3 21 40 40
afg3 23.5 21 49 79 7.21E-01
rpl20b 21.3 22 34 60 8.66E-01
yta12 21.2 22 39 79 8.51E-01
Study: An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast.
Species: Budding yeast
Data: genotype mean median max num pvalue
#background=S288c
WT 28.95 29 51 32 -
AVT1(OE) 37 37 62 32 0.00376
avt1 23 22.5 45 31 0.0045
Study: An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast.
Species: Budding yeast
Data: genotype mean median max num pvalue
#background=S288c
WT 28 28 50 50 -
VMA1(OE) 39 39 80 56 0.0002
Study: An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast.
Species: Budding yeast
Data: genotype treatment mean median max num pvalue
#background=S288c
WT - 31 31.5 50 32 -
WT DR 45 45 75 31 <0.0001
vma2 - 5 5 15 60 <0.0001
vma2 DR 2 2 12 52 0.0398
WT - 29 29 50 38 -
WT DR 44 43.5 76 40 <0.0001
VMA1(OE) - 42 43 75 36 <0.0001
VMA1(OE) DR 40 40 64 38 0.076
Study: An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast.
Species: Budding yeast
Data: genotype mean median max num pvalue
#background=S288c
WT 26 26 50 53 -
VPH2(OE) 32 32.5 67 52 0.0054
Study: Absence of Cardiotrophin 1 Is Associated With Decreased Age-Dependent Arterial Stiffness and Increased Longevity in Mice.
Species: House mouse
Data: genotype median num pvalue
#background=C57BL6
#gender=male
WT 28 18 -
CT-1(null) 33 24 0.007
Study: Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway.
Species: Fruit fly
Data: genotype mean max num pvalue
#background=w1118
+/da-GAL4 26 31 29 -
+/UAS-dTsc1 25 34 109 -
da-GAL4/UAS-dTsc1 29 40 136 <0.0001
+/da-GAL4 26 31 92 -
+/dTsc2 25 34 118 -
da-GAL4/UAS-dTsc2 29 37 112 <0.0001
+/da-GAL4 26 31 92 -
+/UAS-dTORFRB 22 31 98 -
da-GAL4/UAS-dTORFRB 30 40 126 <0.0001
+/da-GAL4 26 31 92 -
+/UAS-dS6KKQ 23 34 115 -
da-GAL4/UAS-dS6kKQ 30 40 122 <0.0001
+/da-GAL4 26 31 92 -
+/UAS-dS6kSDETE 24 31 40 -
da-GAL4/UAS-dS6kSTDETE 16 24 75 <0.0001
+/da-GAL4 58 78 133 -
+/UAS-dTsc2 56 74 126 -
da-GAL4/UAS-dTsc2 69 88 134 <0.0001
+/da-GAL4 48 79 133 -
+UAS-dTORFRB 55 71 128 -
da-GAL4/UAS-dTORFRB 72 89 112 <0.0001
Study: Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway.
Species: Fruit fly
Data: genotype mean max num pvalue
#background=w1118
+/gmr-GAL4 31 42 102 -
+/UAS-dTsc2 27 33 81 -
gmr-GAL4/UAS-dTsc2 27 38 69 <0.01
+/appl-GAL4 32 42 85 -
+/UAS-dTsc2 27 33 81 -
appl-GAL4/UAS-dTsc2 33 42 108 <0.001
+/24B-GAL4 31 34 67 -
+/UAS-dTsc2 27 33 81 -
24B-GAL4/UAS-dTsc2 37 45 107 <0.0001
+/PO188-GAL4 24 28 71 -
+/UAS-dTsc2 27 33 81 -
PO188-GAL4/UAS-dTsc2 35 45 76 <0.0001
+/DJ634-GAL4 24.6 31 120 -
+/UAS-dTsc2 25.3 34 118 -
DJ634-GAL4/UAS-dTsc2 30.6 40 120 <0.0001
+/PO163-GAL4 28 34 87 -
+/UAS-dTsc2 27 33 81 -
PO163-GAL4/UAS-dTsc2 36 45 126 <0.0001
+/DJ634-GAL4 25 31 120 -
+/UAS-dTORFRB 22 31 98 -
DJ634-GAL4/UAS-dTORFRB 31 37 107 <0.0001
+/DJ634-GAL4 25 31 120 -
+/UAS-dS6kKQ 23 34 115 -
DJ634-GAL4/UAS-dS6kKQ 31 40 110 <0.0001
Study: Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway.
Species: Fruit fly
Data: genotype;diet;mean;num;pvalue
#temperature=29
#background=w1118
#separator=;
+/da-GAL4;0.1% yeast extract;33;125
da-GAL4/UAS-dTsc2;0.1% yeast extract;30;164;<0.3
+/da-GAL4;0.3% yeast extract;31;139
da-GAL4/UAS-dTsc2;0.3% yeast extract;33;138;<0.03
+/da-GAL4;1% yeast extract;30;182
da-GAL4/UAS-dTsc2;1% yeast extract;34;164;<0.0001
+/da-GAL4;3% yeast extract;28;181
da-GAL4/UAS-dTsc2;3% yeast extract;34;154;<0.0001
+/da-GAL4;9% yeast extract;12;150
da-GAL4/UAS-dTsc2;9% yeast extract;24;156;<0.0001
Study: Minocycline effect on life and health span of Drosophila melanogaster.
Species: Fruit fly
Data: diet mean max pvalue
#background=Oregon
#gender=female
control 7 23 -
minocycline 11 41 <0.0001
Study: Minocycline effect on life and health span of Drosophila melanogaster.
Species: Fruit fly
Data: diet mean max pvalue
#background=Oregon
#gender=male
control 7 32 -
minocycline 15 41 <0.0002
Study: Age-associated changes in expression of small, noncoding RNAs, including microRNAs, in C. elegans.
Species: Nematode
Data: genotype mean sem num
#background=spe-9(hc88)
#temperature=23
spe-9 8.65 0.22 114
spe-9 8.71 0.24 120
spe-9 8.52 0.21 101
Study: Age-associated changes in expression of small, noncoding RNAs, including microRNAs, in C. elegans.
Species: Nematode
Data: genotype mean sem max num pvalue
#background=spe-9(hc88)
control(RNAi) 9.32 0.24 - 97
alg-1(RNAi) 7.82 0.16 - 90 <0.0001
control(RNAi) 8.5 0.28 - 80
alg-1(RNAi) 7.68 0.16 - 87 0.0005
control(RNAi) 9.59 0.24 - 93
alg-1(RNAi) 8.17 0.16 - 110 <0.0001
control(RNAi) 9.14 0.33 15 -
alg-1(RNAi) 7.89 0.15 10 - <0.0005
Study: Age-associated changes in expression of small, noncoding RNAs, including microRNAs, in C. elegans.
Species: Nematode
Data: temperature mean sem num pvalue
#background=spe-9(hc88)
23 7.46 0.20 105
27 6.27 0.10 113 <0.0001
15 16.58 0.53 81 <0.0001
23 7.77 0.24 98
27 5.94 0.12 101 <0.0001
15 15.83 0.44 90 <0.0001
Study: Age-associated changes in expression of small, noncoding RNAs, including microRNAs, in C. elegans.
Species: Nematode
Data: treatment mean sem num pvalue
#background=spe-9(hc88)
control(RNAi) 10.47 0.42 68
daf-2(RNAi) - - 58 <0.0001
daf-16(RNAi) 8.34 0.31 70 <0.0001
hsf-1(RNAi) 5.69 0.22 70 <0.0001
control(RNAi) 9.97 0.41 71
daf-2(RNAi) - - 75 <0.0001
daf-16(RNAi) 8.39 0.32 65 <0.0001
hsf-1(RNAi) 5.76 0.21 75 <0.0001
Study: MicroRNAs both promote and antagonize longevity in C. elegans.
Species: Nematode
Data: genotype mean max
#temperature=20
#strain=N2
control 17 25
mir-71(n4115) 9 12
mir-238(n4112) 14 19
mir-246(n4636) 15 22
mir-239(nDf62) 19 34
control 13 17
mir-71(OE) 16 26
mir-71(OE) 15 23
mir-71(OE) 17 24
control 16 21
mir-246(OE) 17 24
mir-246(OE) 17 24
mir-246(OE) 17 22
control 15 24
mir-239(OE) 13 18
mir-239(OE) 13 20
mir-239(OE) 13 16
Study: MicroRNAs both promote and antagonize longevity in C. elegans.
Species: Nematode
Data: genotype treatment mean max
#temperature=20
#strain=N2
wt - 18 23
mir-239(nDf62) - 20 27
wt daf-16(RNAi) 13 19
mir-239(nDf62) daf-16(RNAi) 13 18
wt daf-2(RNAi) 29 34
mir-239(nDf62) daf-2(RNAi) 26 33
wt - 19 28
mir-71(n4115) - 9 15
wt daf-2(RNAi) 33 40
mir-71(n4115) - 13 21
wt - 20 24
mir-71(n4115) - 10 14
wt daf-16(RNAi) 14 19
mir-71(n4115) daf-16(RNAi) 10 13
wt - 20 24
mir-71(n4115) - 10 14
wt cdc-25.1(RNAi) 22 27
mir-71(n4115) cdc-25.1(RNAi) 11 14
Study: The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism.
Species: Fruit fly
Data: genotype mean max gender
wt 29 42 female
mir-14 13 27 female
wt 31 42 male
mir-14 22 33 male
Study: The prolongation of the lifespan of rats by repeated oral administration of [60]fullerene.
Species: Norway rat
Data: treatment;mean;median;max;num
#separator=;
#gender=male
#background=Wistar
water-treated;29;22;38;6
Olive oil-treated;41;26;58;6
C60-Olive oil-treated;62;42;66;6
Study: Metformin slows down aging and extends life span of female SHR mice.
Species: Norway rat
Data: treatment mean sem median max num pvalue
Control 388 29.2 297 814 50 -
Metformin 535 31.9 570 898 50 <0.01
# The differences with the controls are significant, p<0.01 (Student t test).
Study: Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice.
Species: House mouse
Data: treatment mean sem max num pvalue
Control 264 3.5 311 34 -
Metformin 285 5.2 340 32 <0.05
Study: Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.
Species: House mouse
Data: genotype max num
WT 1250 60
T-GFP 882 36
T23 1058 57
T-GFP 882 36
T23 1058 57
Study: Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.
Species: House mouse
Data: genotype max num
WT 999 30
T-GFP 882 22
T23 1246 29
T-GFP 882 22
T23 1246 29
Study: Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.
Species: House mouse
Data: genotype max num
WT 1057 30
T-GFP 803 14
T23 1003 28
T-GFP 803 14
T23 1003 28
Study: Autophagy induction extends lifespan and reduces lipids content in response to frataxin silencing in C. elegans.
Species: Nematode
Data: genotype;treatment;mean;sem;max;num;pvalue
#separator=;
WT;control;17.6;0.4;27;-;140;-
WT;frh-1 I(RNAi);18.3;0.5;27;130;0.45750
WT;frh-1 II(RNAi);17.2;0.3;27;140;0.37669
WT;frh-1 III(RNAi);16.7;0.4;27;130;0.61293
WT;frh-1 IV(RNAi);20.9;0.5;37;149;0.000001