| mrps-5 RNAi | Knockdown of mrps-5 throughout the entire life increases the lifespan by 60%. mrps-5 RNAi prevents aging-associated functional decline and alters mitochondrial function. Knocking down mrps-5 after early development no longer affects nematode lifespan. When RNAi of mrps-5 was performed during the larval stages only, lifespan increases by 48%, whereas RNAi started from the L4 stage has no effect. mrps-5 RNAi results in fragmented mitochondria. mrps-5 RNAi increases lifespan by 40% in widltype, 37% in daf-16(mu86), 40% in sir-2.1(ok434) 69% in aak-2(ok524) and 112% in mev-1(kn1). Knockdown of cco-1 does not extend the lifespan of mrps-5 RNAi [23698443]. | Worm | +60 | — | — |
| RPS6B deletion | RPS6B deletion increases mean replicative lifespan by about 30% [16293764]. Deletion of RPS6B, but not of the RPS6A paralog increases replicative median lifespan robustly by 45% [17174052]. | Yeast | +30 | +45 | — |
| RPS6A deletion | Deletion of RPS6A increases replicative lifespan by 30% in alpha strain [18423200; 18340043]. | Yeast | +30 | — | — |
| RPS27B deletion | Deletion of RPS27B decreases mean replicative lifespan decreased by 20 - 30% in the alpha strain [18423200; 19030232] and by 27% in the ORF collection as well as by 14% in the remade strain [22377630]. | Yeast | -14 to -30 | — | — |
| rps-27 RNAi | Knockdown of rps-27 by RNAi extends mean and maximum lifespan by 50 and 44%, respectively [19293945]. | Worm | +50 | — | +44 |
| rps-23 RNAi | Knockdown of rps-23 via RNAi started after the animal reached the late L4 stage increases mean and maximum lifespan by 16-23% [22103665]. | Worm | +16 to +23 | — | — |
| rps-11 RNAi | Knockdown of rps-11 via RNAi started after the animal reached the late L4 stage increases mean lifespan by 14-30% [22103665]. | Worm | +14 to +30 | — | — |
| rps-20 RNAi | Knockdown of rps-20 via RNAi started after the animal reached the late L4 stage increases mean lifespan by 10-24% with no affect on maximum lifespan [22103665]. | Worm | +10 to +24 | — | 0 |
| rps-0 RNAi | Knockdown of rps-0 via RNAi started after the animal reached the late L4 stage extends mean lifespan by 15-21%, but decreases maximum lifespan by 8% [22103665]. | Worm | +15 to +21 | — | -8 |
| rps-5 RNAi | Knockdown of rps-5 via RNAi started after the animal reached the late L4 stage extend mean lifespan by 4 to 20% [22103665]. | Worm | +4 to +20 | — | — |
| rps-15 RNAi | Knockdown of rps-15 via RNAi started after the animal reaches the late L4 stage increases mean and maximum lifespan by 9-12% and 16%, respectively [22103665]. | Worm | +9 to +12 | — | +16 |
| rps-16 RNAi | Knockdown of rps-16 via RNAi started after the animal reached the L4 stage increases mean and maximum lifespan by 8-17% and 16%, respectively [22103665]. | Worm | +8 to +17 | — | +16 |
| rps-7 RNAi | RNAi against rps-7 strated after the animal reaches the late L4 stage increases mean lifespan by 15-16% [22103665]. | Worm | +15 to +16 | — | — |
| rps-9 RNAi | rps-9 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| rps-14 RNAi | rps-14 RNAi in the adulthood extends mean and maximum lifespan by 17 and 22% [23144747]. Knockdown of rps-14 via RNAi started after the animal reached the late L4 stage extends lifespan by 6-19% [22103665]. | Worm | +6 to +19 | — | +21.7 |
| rps-12 RNAi | rps-12 RNAi in the adulthood extends mean and maximum lifespan by 12 and 22%, respectively [23144747]. | Worm | +11.6 | — | +21.7 |
GenAge
GenDR
