Interventions

  • name effect species mean median maximum
    mrps-5 RNAi Knockdown of mrps-5 throughout the entire life increases the lifespan by 60%. mrps-5 RNAi prevents aging-associated functional decline and alters mitochondrial function. Knocking down mrps-5 after early development no longer affects nematode lifespan. When RNAi of mrps-5 was performed during the larval stages only, lifespan increases by 48%, whereas RNAi started from the L4 stage has no effect. mrps-5 RNAi results in fragmented mitochondria. mrps-5 RNAi increases lifespan by 40% in widltype, 37% in daf-16(mu86), 40% in sir-2.1(ok434) 69% in aak-2(ok524) and 112% in mev-1(kn1). Knockdown of cco-1 does not extend the lifespan of mrps-5 RNAi [23698443]. Worm +60
    RPS6B deletion RPS6B deletion increases mean replicative lifespan by about 30% [16293764]. Deletion of RPS6B, but not of the RPS6A paralog increases replicative median lifespan robustly by 45% [17174052]. Yeast +30 +45
    RPS6A deletion Deletion of RPS6A increases replicative lifespan by 30% in alpha strain [18423200; 18340043]. Yeast +30
    RPS27B deletion Deletion of RPS27B decreases mean replicative lifespan decreased by 20 - 30% in the alpha strain [18423200; 19030232] and by 27% in the ORF collection as well as by 14% in the remade strain [22377630]. Yeast -14 to -30
    rps-27 RNAi Knockdown of rps-27 by RNAi extends mean and maximum lifespan by 50 and 44%, respectively [19293945]. Worm +50 +44
    rps-23 RNAi Knockdown of rps-23 via RNAi started after the animal reached the late L4 stage increases mean and maximum lifespan by 16-23% [22103665]. Worm +16 to +23
    rps-11 RNAi Knockdown of rps-11 via RNAi started after the animal reached the late L4 stage increases mean lifespan by 14-30% [22103665]. Worm +14 to +30
    rps-20 RNAi Knockdown of rps-20 via RNAi started after the animal reached the late L4 stage increases mean lifespan by 10-24% with no affect on maximum lifespan [22103665]. Worm +10 to +24 0
    rps-0 RNAi Knockdown of rps-0 via RNAi started after the animal reached the late L4 stage extends mean lifespan by 15-21%, but decreases maximum lifespan by 8% [22103665]. Worm +15 to +21 -8
    rps-5 RNAi Knockdown of rps-5 via RNAi started after the animal reached the late L4 stage extend mean lifespan by 4 to 20% [22103665]. Worm +4 to +20
    rps-15 RNAi Knockdown of rps-15 via RNAi started after the animal reaches the late L4 stage increases mean and maximum lifespan by 9-12% and 16%, respectively [22103665]. Worm +9 to +12 +16
    rps-16 RNAi Knockdown of rps-16 via RNAi started after the animal reached the L4 stage increases mean and maximum lifespan by 8-17% and 16%, respectively [22103665]. Worm +8 to +17 +16
    rps-7 RNAi RNAi against rps-7 strated after the animal reaches the late L4 stage increases mean lifespan by 15-16% [22103665]. Worm +15 to +16
    rps-9 RNAi rps-9 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    rps-14 RNAi rps-14 RNAi in the adulthood extends mean and maximum lifespan by 17 and 22% [23144747]. Knockdown of rps-14 via RNAi started after the animal reached the late L4 stage extends lifespan by 6-19% [22103665]. Worm +6 to +19 +21.7
    rps-12 RNAi rps-12 RNAi in the adulthood extends mean and maximum lifespan by 12 and 22%, respectively [23144747]. Worm +11.6 +21.7
    • 16 interventions
    Interventions are an extension of GenAge and GenDR.