Denigma: Intervention

SIR3 activating mutation

Species: Budding yeast (Taxid: 4932)
Factor: SIR3
Manipulation: Gain-of-Function, Mutation
Effect:

The S755A allele of SIR3 (which prevents phosphorylation of Sir3) results in a 40% increase in mean and maximum lifespan [12640455].

Mean: +40
Maximum: +40

Aging Relevance Analysis/Source:

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