Males heterozygous for hypomorphic (partial loss-of-function) mutation of Rpd3 have a lifespan extension of 33%. Females heterozygous for a hypomorphic allele have a 52% increase in lifespan. Longevity increases to the same extent in wild-type under low-calorie diet and rpd3 mutants fed normal diet [12459580].
Mean: +33 to 52
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