LF - filled Lysms have reduced capac & reduced rate of digesting Junk. They demand more lytic enzymes from Golgi, so less enzymes go to functional Lysosomes. Apgy becomes inhibited when Lysms cannot accept more junk. -yellow-> Reactive Aggs, giant mitochondria, & LF-filled Lysosomes accumulate in cytoplasm, generate ROS, & impaircell functioning
