Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
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    ‑ (19)   Candidate Region/Gene (382)   Meta‑Analysis (8)   Genome‑Wide Association Study (103)   Mitochondrial Haplogroup (27)  
  • Variant type: + -
    SNP (314)   Haplotype (43)   Other (1)   STR (7)   Deletion (1)  
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs419010 PVRL2 1.13 0.091 597 vs 1275 — Sichuan 90+ — — Candidate Region/Gene 24924924
    rs4803766 PVRL2 0.97 0.708 597 vs 1275 — Sichuan 90+ — — Candidate Region/Gene 24924924
    rs11879589 PVRL2 1.67 0.07601 597 vs 1275 — Sichuan 90+ — — Candidate Region/Gene 24924924
    rs519113 PVRL2 0.90 0.3734 597 vs 1275 — Sichuan 90+ — — Candidate Region/Gene 24924924
    rs6857 PVRL2 0.90 0.518 597 vs 1275 — Sichuan 90+ — — Candidate Region/Gene 24924924
    rs10119 TOMM40 0.94 0.914 597 vs 1275 — Sichuan 90+ — — Candidate Region/Gene 24924924
    rs449647 APOE 1.01 0.767 597 vs 1275 — Sichuan 90+ — — Candidate Region/Gene 24924924
    rs440446 APOE 1083.00 0.509 597 vs 1275 — Sichuan 90+ — — Candidate Region/Gene 24924924
    rs769448 APOE 1.09 0.66 597 vs 1275 — Sichuan 90+ — — Candidate Region/Gene 24924924
    rs769449 APOE 0.90 0.62 597 vs 1275 — Sichuan 90+ — — Candidate Region/Gene 24924924
    rs7412 APOE 1.15 0.405 597 vs 1275 — Sichuan 90+ — — Candidate Region/Gene 24924924
    rs429538 APOE 0.88 0.2821 597 vs 1275 — Sichuan 90+ — — Candidate Region/Gene 24924924
    rs4420638 — 0.85 0.176 597 vs 1275 — Sichuan 90+ — — Candidate Region/Gene 24924924
    rs2153960 FOXO3A — 1.0 1435 vs 2098 — Multiethnic 90+ — — Meta-Analysis 25038186
    rs7762395 FOXO3A — 1.0 2832 vs 2168 — Multiethnic 90+ — — Meta-Analysis 25038186
    rs13220810 FOXO3A — 1.0 1746 vs 1219 — Multiethnic 90+ — — Meta-Analysis 25038186
    rs5882 CETP — 0.63 — — Multiethnic — — — Meta-Analysis 24468472
    rs708272 CETP — 0.53 — — Multiethnic — — — Meta-Analysis 24468472
    rs662 PON1 1.06 0.11 — — Danish, Dutch, French, German, Italian, Tatar >/=80 — — Candidate Region/Gene 20362697
    APOE e2,e3,e4 APOE — 0.05 185 vs 486 — Finn Over 100 E4 e2 Candidate Region/Gene 8018664
    rs1800587 IL1A — 0.31 250 vs 400 — Finn >90 — — Candidate Region/Gene 11640949
    rs16944 IL1B — 0.08 250 vs 400 — Finn >90 — — Candidate Region/Gene 11640949
    rs1143634 IL1B — 0.53 250 vs 400 — Finn >90 — — Candidate Region/Gene 11640949
    rs1800795 IL6 — 0.23 250 vs 400 — Finn >90 — — Candidate Region/Gene 11640949
    rs1800896 IL10 — 0.64 250 vs 400 — Finn >90 — — Candidate Region/Gene 11640949
    • Page 1 of 22
    • 25 of 543 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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