A developmental timing microRNA and its target regulate life span in C. elegans.

Authors: Boehm, Michelle; Slack, Frank
Year: 2005
Journal: Science
Abstract: The microRNA lin-4 and its target, the putative transcription factor lin-14, control the timing of larval development in Caenorhabditis elegans. Here, we report that lin-4 and lin-14 also regulate life span in the adult. Reducing the activity of lin-4 shortened life span and accelerated tissue aging, whereas overexpressing lin-4 or reducing the activity of lin-14 extended life span. Lifespan extension conferred by a reduction in lin-14 was dependent on the DAF-16 and HSF-1 transcription factors, suggesting that the lin-4-lin-14 pair affects life span through the insulin/insulin-like growth factor-1 pathway. This work reveals a role for microRNAs and developmental timing genes in life-span regulation.
Reference

Integration:

Created on Nov. 5, 2012, 5:57 p.m.
Not linked
Integrated: False

No notes
Species: Nematode

Experiments: 0
Interventions:

lin-14 gain-of-function mutation

lin-4 mutation

lin-4 overexpression

lin-14 loss-of-function mutation

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