Increased longevity of some C. elegans mitochondrial mutants explained by activation of an alternative energy-producing pathway.
Authors: Gallo, Marco; Park, Donha; Riddle, Donald L Year: 2011 Journal: Mech Ageing Dev Abstract: The Caenorhabditis elegans misc-1 gene encodes a mitochondrial carrier with a role in oxidative stress response. The knock-out mutant has no lifespan phenotype and fails to upregulate the gei-7-mediated glyoxylate shunt, an extra-mitochondrial pathway of energy production. We show that gei-7 is required for the longevity of the mitochondrial mutant clk-1. Our data suggest that only mitochondrial mutants that upregulate gei-7 can achieve longevity. Reference
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