Enigma, a mitochondrial protein affecting lifespan and oxidative stress response in Drosophila.

Authors: Mourikis P; Hurlbut GD; Artavanis-Tsakonas S
Year: 2006
Journal: Proceedings of the National Academy of Sciences of the United States of America
Abstract: Deregulation of energy metabolism by external interventions or mutations in metabolic genes can extend lifespan in a wide range of species. We describe mutations in Drosophila melanogaster that confer resistance to oxidative stress and display a longevity phenotype. These phenotypes are associated with molecular lesions in a hitherto uncharacterized gene we named Enigma. We show that Enigma encodes a mitochondrial protein with homology to enzymes of the beta-oxidation of fatty acids and that mutations in this locus affect lipid homeostasis. Our analysis provides further support to the notion that lipid metabolism may play a central role in metazoan lifespan regulation.
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Integration:

Created on Nov. 7, 2012, 7:16 p.m.
Not linked
Integrated: False

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Species: Fruit fly

Experiments: 0
Interventions:

egm mutation

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