Extended life-span conferred by cotransporter gene mutations in Drosophila.

Authors: Rogina B; Reenan RA; Nilsen SP; Helfand SL
Year: 2000
Journal: Science (New York, N.Y.)
Abstract: Aging is genetically determined and environmentally modulated. In a study of longevity in the adult fruit fly, Drosophila melanogaster, we found that five independent P-element insertional mutations in a single gene resulted in a near doubling of the average adult life-span without a decline in fertility or physical activity. Sequence analysis revealed that the product of this gene, named Indy (for I'm not dead yet), is most closely related to a mammalian sodium dicarboxylate cotransporter-a membrane protein that transports Krebs cycle intermediates. Indy was most abundantly expressed in the fat body, midgut, and oenocytes: the principal sites of intermediary metabolism in the fly. Excision of the P element resulted in a reversion to normal life-span. These mutations may create a metabolic state that mimics caloric restriction, which has been shown to extend life-span.
Reference

Integration:

Created on Nov. 6, 2012, 11:53 a.m.
Not linked
Integrated: False

No notes
Species: Fruit fly

Experiments: 0
Interventions:

Indy mutation

Edit study (Admin) | Add experiment to study (Admin) | Delete study

---

Back to top

---