Suppression of aging in mice by the hormone Klotho.

Authors: Kurosu H; Yamamoto M; Clark JD; Pastor JV; Nandi A; Gurnani P; McGuinness OP; Chikuda H; Yamaguchi M; Kawaguchi H; Shimomura I; Takayama Y; Herz J; Kahn CR; Rosenblatt KP; Kuro-o M
Year: 2005
Journal: Science (New York, N.Y.)
Abstract: A defect in Klotho gene expression in mice accelerates the degeneration of multiple age-sensitive traits. Here, we show that overexpression of Klotho in mice extends life span. Klotho protein functions as a circulating hormone that binds to a cell-surface receptor and represses intracellular signals of insulin and insulin-like growth factor 1 (IGF1), an evolutionarily conserved mechanism for extending life span. Alleviation of aging-like phenotypes in Klotho-deficient mice was observed by perturbing insulin and IGF1 signaling, suggesting that Klotho-mediated inhibition of insulin and IGF1 signaling contributes to its anti-aging properties. Klotho protein may function as an anti-aging hormone in mammals.
Reference

Integration:

Created on Nov. 6, 2012, 10:52 a.m.
Not linked
Integrated: False

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Species: House mouse

Experiments: 0
Interventions:

Klotho overexpression

Klotho disruption

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