346 | Figure 2. Dependence of Lifespan Extension on Overexpression in Specific Tissues | ✔ | w1118 | +/DJ634-GAL4 | — | — | — | — | 24.6 | — | 31.0 | 120 |
345 | Figure 2. Dependence of Lifespan Extension on Overexpression in Specific Tissues | ✘ | w1118 | PO188-GAL4/UAS-dTsc2 | — | — | — | — | 35.0 | — | 45.0 | 76 |
344 | Figure 2. Dependence of Lifespan Extension on Overexpression in Specific Tissues | ✘ | w1118 | +/UAS-dTsc2 | — | — | — | — | 27.0 | — | 33.0 | 81 |
348 | Figure 2. Dependence of Lifespan Extension on Overexpression in Specific Tissues | ✘ | w1118 | DJ634-GAL4/UAS-dTsc2 | — | — | — | — | 30.6 | — | 40.0 | 120 |
350 | Figure 2. Dependence of Lifespan Extension on Overexpression in Specific Tissues | ✘ | w1118 | +/UAS-dTsc2 | — | — | — | — | 27.0 | — | 33.0 | 81 |
349 | Figure 2. Dependence of Lifespan Extension on Overexpression in Specific Tissues | ✔ | w1118 | +/PO163-GAL4 | — | — | — | — | 28.0 | — | 34.0 | 87 |
347 | Figure 2. Dependence of Lifespan Extension on Overexpression in Specific Tissues | ✘ | w1118 | +/UAS-dTsc2 | — | — | — | — | 25.3 | — | 34.0 | 118 |
343 | Figure 2. Dependence of Lifespan Extension on Overexpression in Specific Tissues | ✔ | w1118 | +/PO188-GAL4 | — | — | — | — | 24.0 | — | 28.0 | 71 |
336 | Figure 2. Dependence of Lifespan Extension on Overexpression in Specific Tissues | ✘ | w1118 | gmr-GAL4/UAS-dTsc2 | — | — | — | — | 27.0 | — | 38.0 | 69 |
354 | Figure 2. Dependence of Lifespan Extension on Overexpression in Specific Tissues | ✘ | w1118 | DJ634-GAL4/UAS-dTORFRB | — | — | — | — | 31.0 | — | 37.0 | 107 |
353 | Figure 2. Dependence of Lifespan Extension on Overexpression in Specific Tissues | ✘ | w1118 | +/UAS-dTORFRB | — | — | — | — | 22.0 | — | 31.0 | 98 |
525 | Fig. 3. Animal survival and growth | ✘ | Wistar | — | Mutation | — | — | — | 62.0 | 42.0 | 66.0 | 6 |
577 | Table 1 Lifespan analyses frh-1 dsRNA constructs - summary statistics | ✘ | — | WT | RNA Interference | frh-1 IV(RNAi) | — | — | 20.9 | — | 37.0 | 149 |
528 | Table 4 Effect of metformin on parameters of life span in female HER-2/neu mice | ✔ | — | — | Mutation | — | — | — | 264.0 | — | 311.0 | 34 |
524 | Fig. 3. Animal survival and growth | ✘ | Wistar | — | Mutation | — | — | — | 41.0 | 26.0 | 58.0 | 6 |
352 | Figure 2. Dependence of Lifespan Extension on Overexpression in Specific Tissues | ✔ | w1118 | +/DJ634-GAL4 | — | — | — | — | 25.0 | — | 31.0 | 120 |
351 | Figure 2. Dependence of Lifespan Extension on Overexpression in Specific Tissues | ✘ | w1118 | PO163-GAL4/UAS-dTsc2 | — | — | — | — | 36.0 | — | 45.0 | 126 |
335 | Figure 2. Dependence of Lifespan Extension on Overexpression in Specific Tissues | ✘ | w1118 | +/UAS-dTsc2 | — | — | — | — | 27.0 | — | 33.0 | 81 |
211 | Figure 4 | Calorie restriction extends lifespan by regulating vacuolar acidity. | ✘ | S288c | vma2 | — | — | — | — | 5.0 | 5.0 | 15.0 | 60 |
193 | Figure 3 | Reduced vacuolar acidity causes mitochondrial dysfunction by disrupting amino acid homeostasis. | ✔ | S288c | WT | — | — | — | — | 28.95 | 29.0 | 51.0 | 32 |
194 | Figure 3 | Reduced vacuolar acidity causes mitochondrial dysfunction by disrupting amino acid homeostasis. | ✘ | S288c | AVT1(OE) | — | — | — | — | 37.0 | 37.0 | 62.0 | 32 |
195 | Figure 3 | Reduced vacuolar acidity causes mitochondrial dysfunction by disrupting amino acid homeostasis. | ✘ | S288c | avt1 | — | — | — | — | 23.0 | 22.5 | 45.0 | 31 |
196 | Figure 2 | Vacuolar acidity is reduced in ageing cells and regulates mitochondrial function and lifespan. | ✔ | S288c | WT | — | — | — | — | 28.0 | 28.0 | 50.0 | 50 |
197 | Figure 2 | Vacuolar acidity is reduced in ageing cells and regulates mitochondrial function and lifespan. | ✘ | S288c | VMA1(OE) | — | — | — | — | 39.0 | 39.0 | 80.0 | 56 |
209 | Figure 4 | Calorie restriction extends lifespan by regulating vacuolar acidity. | ✔ | S288c | WT | — | — | — | — | 31.0 | 31.5 | 50.0 | 32 |