APD1 | Actin Patches Distal 1 | Although APD1 was identified as a potential long-lived mutant strain in a bar-code screen, deletion of APD1 does not significantly affect chronological lifespan under starvation/extreme DR [20657825]. | Budding yeast |
ATG18 | — | The replicative lifespan of ATG18 deletion mutant is not shorter than that of wild-type under DR [18690010]. | Budding yeast |
BUL1 | Binds Ubiquitin Ligase 1 | Deletion of BUL1 does non-significantly reduces mean chronological lifespan under starvation/extreme DR [20657825]. | Budding yeast |
CIT2 | CITrate synthase 2 | Deletion or overexpression of CIT2 has no effect on replicative lifespan. CIT2 is not required for the strain specific lifespan extension in petite cells [10224252], although it is transcribed up to 30-fold higher in petite cells relative to grande cells [1986232]. | Budding yeast |
CPR7 | Cyclosporin-sensitive Proline Rotamase 7 | Deletion of CPR7 has no effect on lifespan replicative lifespan, but increases chronological lifespan [11361336] | Budding yeast |
CYT1 | cytochrome c1 | Deletion of CYT1 increases replicative lifespan by 15% in the alpha strain and decreases replicative lifespan by 20% in a strain. Deletion of CYT1 decreases replicative lifespan and cancels out replicative lifespan extension by HAP4 overexpression. Initially, it was shown that deletion of CYT1 also prevents lifespan extension by 0.5% glucose restriction [12124627], but later it was shown that either 0.5 or 0.05 % glucose restriction increases replicative lifespan of cyt1Delta cells [16311627]. | Budding yeast |
DNL4 | DNA Ligase 4 | DNL4 deletion does not affect lifespan [10521401], although it renders cells defective for non-homologous end-joining [9242411] | Budding yeast |
FCY1 | FluoroCYtosine resistance 1 | Deletion of FCY1 does non-significantly decrease mean and maximum replicative lifespan by 4% and 8%, respectively [20550517]. | Budding yeast |
GAL83 | GALactose metabolism 83 | Deletion of GAL83 has no effect on replicative lifespan in S228C [10921902] and general GAL83 mutants have no obvious phenotype [10990457]. | Budding yeast |
HDA1 | Histone DeAcetylase 1 | Deletion of HDA1 has no effect on longevity under AL, but acts synergistically with 0.1% glucose restriction to increase replicative lifespan [12213553]. Deletion of HDA1 leads to a slightly increased chronological lifespan [19801973]. Deletion of HDA1 has no effect on the wild-type lifespan in the short-lifespan of YSK771 strain, but suppresses the short-lifespan of SIR3 mutants [10512855]. | Budding yeast |
IMD2 | IMP Dehydrogenase 2 | Deletion of IMD2 does non-significantly decrease mean replicative lifespan by 1% and non-significantly increased maximum replicative lifespan by 21% [20550517]. | Budding yeast |
MXR2 | peptide Methionine sulfoXide Reductase 2 | Deletion or overexpression of MXR2 (alias MsrB) has no effect on replicative lifespan under normal growth conditions. Simulatonous deletion of MXR2 together with MXR1 dramatically reduces replicative lifespan by 63%. Overexpression of MXR2 under DR conditions extends replicative lifespan by 120% [15141092]. | Budding yeast |
OSH7 | OxySterol binding protein Homolog 7 | Overexpression of OSH7 extends mean replicative lifespan. PERG6-OSH7 does not extend the maximum lifespan significantly [Xia et al., unpublished].
Deletion of the CC domain of Osh7 (Perg6-OSH7-ORD) greatly shortens the lifespan. Deletion of the Osh7's CC domain decreases lifespan (Perg6-OSH7-ORD) shortens the lifespan [Tang et al., personal communication].
Osh7 interacts with the late endosome ATPase Vps4 by their C-terminal coiled-coil (CC) domain. | Budding yeast |
PAN2 | Poly(A)-binding protein-dependent poly(A) riboNuclease 2 | Deletion mutant of PAN2 live approximately as long as wild-type under starvation/extreme DR [20657825]. | Budding yeast |
PUF4 | PUmilio-homology domain Family 4 | Deletion of PUF4 has no effect on replicative lifespan in either uth4-14c (C-terminal truncation) or UTH4 background. However, PUF4 is required for lifespan extension by the semi-dominant Sir4-42 allele in the uth4-14c background [9150138].
PUF4 is required for nucleolar relocalization of Sir3 in a Sir4-42 background [9150138]. puf4;mpt5 double deletion strain has increased telomere silencing relative to the mpt5 single mutant [9651685]. | Budding yeast |
RAD1 | RADiation sensitive 1 | Deletion of RAD1 has no effect on replicative lifespan [10207108]. | Budding yeast |
RAD26 | RADiation sensitive 26 | Deletion of RAD26 has no effect on replicative lifespan in PSY316 [10207108]. | Budding yeast |
RAD7 | RADiation sensitive 7 | Deletion of RAD7 has no effect on replicative lifespan in PSY316 [10207108].
Mutation in RAD7 results in decrease repair of the non-transcribed strand in rDNA [8604332]. | Budding yeast |
SLT2 | Suppression at Low Temperature 2 | Deletion of SLT2 has no effect on replicative lifespan in W303 strain [12640455].
SLT2 deletion increases rDNA silencing and rDNA recombination and decreases silencing at the telomeres and HM loci [Ray et al., 2003] as well as results in decreased phosphorylation of Sir3 [12640455]. | Budding yeast |
SML1 | Suppressor of Mec1 Lethality 1 | Deletion of SML1 increases non-significantly mean replicative lifespan by 3% and non-significantly maximum lifespan by 16% [20550517]. | Budding yeast |
SSN2 | Suppressor of SNf1 | Although SSN2 was identified as a potential long-lived mutant strain in a bar-code screen, deletion of SSN2 does not significantly affect chronological lifespan under starvation/extreme DR [20657825]. | Budding yeast |
STE12 | STErile 12 | Deletion of STE12 has no effect on replicative lifespan in strain PSY142 or BKY1-14c [7859289].
STE12 null mutants are sterile [6993497]. | Budding yeast |
TAD1 | tRNA-specific Adenosine Deaminase 1 | Deletion of TAD1 does non-significantly increase the mean replicative lifespan by 14% [20550517]. | Budding yeast |
TPS2 | Trehalose-6-phosphate PhoSphatase 2 | Deletion of TPS2 has no effect on replicative lifespan and does not prevent lifespan extension by high osmolarity [12391171].
TPS2 is required for trehalose biosynthesis in response to osmotic stress [8444170]. | Budding yeast |
UGA2 | Utilization of GAba 2 | Deletion of UGA2 does not affect replicative lifespan [21371425]. | Budding yeast |