| wah-1 | Worm AIF (apoptosis inducing factor) Homolog | wah-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. RNAi against wah-1 started after the animal reaches the late L4 stage extends mean lifespan by 7-8% [22103665]. | Nematode |
| VWA5A | von Willebrand factor A domain containing 5A | VWA5A was found to be associated with longevity [21782286]. | Human |
| VPS36 | Vacuolar Protein Sortin 36 | VPS36 deletion mutants have a chronological lifespan as long as wild type BY4741. Thus, Vps36 is not necessary for the starvation/extreme DR-dependent lifespan extension [20657825]. | Budding yeast |
| VPS30 | Vacuolar Protein Sorting 30 | VPS30 deletion prevents chronological lifespan extension induced by amino-acid DR [20421943]. | Budding yeast |
| VPS20 | Vacuolar Protein Sorting 20 | VPS20 deletion decreases mean and maximum replicative lifespan by 16% and 19%, respectively, and additionally cancels out the DR-induced replicative lifespan extension [22912585]. | Budding yeast |
| VPS13D | vacuolar protein sorting 13 homolog D (S. cerevisiae) | VPS13D was found to be associated with longevity [22279548]. | Human |
| vps-34 | related to yeast Vacuolar Protein Sorting factor 34 | vps-34 RNAi does not significantly change lifespan of wild-type, but cancels out the lifespan extension effect of eat-2 mutation [18282106]. | Nematode |
| VMA2 | Vacuolar Membrane Atpase 2 | VMA2 deletion mutants have a reduced ΔΨ and mitochondrial morphology similar to aged cells. The restoration of the vacuolar acidity in daughter cells requires V-ATPase activity as it is eliminated in VMA2 deletion mutant cells [23172144]. VMA2 deletion mutation decreases the mean replicative lifespan by 80% in the alpha strain [18340043]. Deletion of VMA2 decreases mean, median and maximum replicative lifespan by 84%, 84% and 70%, respectively. DR (0.5% glucose restriction) does not extend the replicative lifespan of VMA2 and shortens it even more [23172144]. | Budding yeast |
| Vitamin D receptor | vitamin D (1,25- dihydroxyvitamin D3) receptor | Vitamin D receptor was not found to be associated with longevity [21051524]. | Human |
| vit-2 | VITellogenin structural genes (yolk protein genes) | vit-2 RNA interference extends mean lifespan by 21-24%. vit-2 is differentially transcribed in daf-16 and daf-2 RNAi animals [12845331].
vit-2 functions in germ-line development by regulating the abundance of native versus oxidized LDL-like lipoproteins [11408580]. | Nematode |
| vit-1 | Vitellogenin-1 | vit-1 RNAi animals have a mean lifespan that 103.3% of controls, but not significant different. vit-1 is differentially expressed in daf-16 and daf-2 RNAi animals [12845331]. | Nematode |
| vig-1 | VIG (Drosophila Vasa Intronic Gene) ortholog | vig-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| VEGFA | vascular endothelial growth factor A | VEGFA was found to be associated with longevity [17574707]. VEGFA was not found to be associated with longevity [17574707]. | Human |
| Vegf | Vascular endothelial growth factor A | Vegf exhibits rhythmic expression in the liver [17360649]. Vegf expression is affected by the circadian organization of molecular clockwork. Levels of Vegf mRNA fluctuate in a circadian fashion. Period2 and Cryptochrome inhibit the Vegf promoter [14612524]. | House mouse |
| VDR | vitamin D (1,25- dihydroxyvitamin D3) receptor | VDR was found to be associated with longevity [21051524]. VDR was not found to be associated with longevity [20407924]. VDR was found to be associated with longevity [20407924]. | Human |
| VASH1 | vasohibin 1 | VASH1 was found to be associated with longevity [22279548]. | Human |
| VAM7 | VAcuolar Morphogenesis 7 | VAM7 deletion decreases replicative lifespan under AL and blocked DR-mediated lifespan extension. Replicative lifespan decreases by 70% on DR in VAM7 deletion mutant [18690010]. | Budding yeast |
| VAC14 | VACuole morphology and inheritance mutant 14 | VAC14 mutants have a single vacuole and shortened lifespan on normal media [16293764]. | Budding yeast |
| vab-1 | Variable ABnormal morphology | vab-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| utx-1 | human UTX (Ubiquitously transcribed TPR on X) homolog | utx-1 RNAi extended mean lifespan by 30%, dependent on DAF-16 activity and not additive in daf-2 mutants [21803287]. utx-1 heterogous knockout also extended lifespan. | Nematode |
| upstream of FOXO3A | — | upstream of FOXO3A was found to be associated with longevity [19196970]. | Human |
| Upstram of FOXO3A | — | Upstram of FOXO3A was found to be associated with longevity [19196970]. | Human |
| gpa-1 | G Protein, Alpha subunit | Up to 10% maximum lifespan extension in gpa-1 knockouts and a 10% decrease when gpa-1 is overexpressed. Loss-of-function of gpa-1 did not extend the lifespan of daf-2 mutants. | Nematode |
| gpc-1 | G Protein, Gamma subunit | Up to 10% increase in mean lifespan in knockouts, dependent on daf-16. | Nematode |
| ARO7 | AROmatic amino acid requiring 7 | Under starvation/extreme DR deletion of ARO7 increases mean chronological lifespan and confers higher resistance to heat-shock, but made cell more sensitive to acetic acid and leads to growth defects. In W303-1A background ARO7 deletion causes an even more severe growth defect and mutants are short-lived [20657825]. | Budding yeast |
