Symbol: MDH1
Name: Malate DeHydrogenase 1
Entrez gene ID: 853777
Ensembl gene ID: YKL085W
Species: Yeast
(Taxid: 4932)
Functional description:
Mdh1p; Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated [Source:SGD;Acc:S000001568] [Ensembl]
Observation:
Overexpression of MDH1 extends replicative lifespan by 25% and does not synergize with 0.5% glucose restriction [18381895].
Interventions:
MDH1 overexpression
+25%
Assays:
Replicative Lifespan
Classification:
Aging-Suppressor
Positive Aging-Suppressor
DR-Essential
Aging Relevance Analysis/Source:
GenAge
GenDR
Homologs
MDH2
(9606)
MDH2
(9598)
MDH2
(9615)
Mdh2
(10090)
Mdh2
(10116)
MDH2
(9031)
zgc:64133
(7955)
CG7998
(7227)
AgaP_AGAP001903
(7165)
mdh-1
(6239)
SPCC306.08c
(4896)
MDH1
(4932)
KLLA0F25960g
(28985)
GeneID:2680415
(148305)
NCU04899
(5141)
AT1G53240
(3702)
AT3G15020
(3702)
Os01g0649100
(4530)
Os05g0574400
(4530)
Orthologs
SPCC306.08c
(4896)
Mdh2
(10116)
Mdh2
(10090)
CG10748
(7227)
CG10749
(7227)
MDH2
(9606)
mdh-1
(6239)
CG7998
(7227)
LOC719983
(9544)
SPCC306.08c
(4896)
Mdh2
(10116)
Mdh2
(10090)
CG10748
(7227)
CG10749
(7227)
MDH2
(9606)
mdh-1
(6239)
CG7998
(7227)
LOC719983
(9544)
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