Symbol: DOA4 Name: Degradation Of Alpha 4 Alias: DOS1;MUT4;NPI2;SSV7;UBP4 Entrez gene ID: 851641 Ensembl gene ID: YDR069C Species: Yeast (Taxid: 4932) Functional description: Doa4p; Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole [Source:SGD;Acc:S000002476] [Ensembl] Observation: Deletion of DOA4 decreases replicative lifespan by 50% in the alpha strain [19030232]. Assays: Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
Comment on This Data Unit