Symbol: VhaSFD Name: Vacuolar H+-ATPase SFD subunit Entrez gene ID: 34997 Ensembl gene ID: FBgn0027779 Species: Fly (Taxid: 7227) Functional description: involved in acidification of energization of organelles; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). [UniProt] Observation: Overexpression of VhaSFD (from a doxycycline-inducible promoter) results in a 5-10% increase in mean lifespan [12620118]. Interventions: Assays: Organismal Lifespan Mean: +5 to +10% Classification: Aging Relevance Analysis/Source: Homologs Inparanoids Edit \ Update (Admin) | Delete |
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