Symbol: UCP2 Name: uncoupling protein 2 (mitochondrial, proton carrier) Entrez gene ID: 7351 Ensembl gene ID: Y40G12A.1 Species: Human (Taxid: 9606) Functional description: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. [UniProt] Observation: Overexpression of human UCP2 in the fly nervous system extends lifespan by 10-30%. Ubiquitous overexpression is lethal [16054055]. Interventions: Assays: Organismal Lifespan Mean: +10 to +30 Classification: Type: References: Aging Relevance Analysis/Source: Homologs Inparanoids Note: This gene is falsely annotated as a fly gene in GenAge. Edit \ Update (Admin) | Delete |
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