Symbol: Trx-2 Name: thioredoxin-2 Entrez gene ID: 34281 Ensembl gene ID: FBgn0040070 Species: Fly (Taxid: 7227) Functional description: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. As a reducing substrate of peroxiredoxin 1, thioredoxin 2 is preferred over thioredoxin 1. [UniProt] Observation: Trx-2 mutants have a 25% reduction in maximum lifespan and exhibit lower tolerance to oxidative stress while animals carrying multiple copies of Trx-2 exhibit higher tolerance [17567437]. Interventions: Assays: Organismal Lifespan Maximum: -25 Classification: Type: References: Aging Relevance Analysis/Source: Homologs Orthologs Inparanoids Edit \ Update (Admin) | Delete |
Comment on This Data Unit