Symbol: skr-1 Name: SKp1 Related (ubiquitin ligase complex component) Entrez gene ID: 172775 Ensembl gene ID: F46A9.5 Species: Worm (Taxid: 6239) Functional description: Protein SKR-1; SKp1 Related (ubiquitin ligase complex component) family member (skr-1) [Source:RefSeq peptide;Acc:NP_492513] [Ensembl]; The skr-1 gene encodes a homolog of Skp1 in S. cerevisiae that is required for the restraint of cell proliferation, progression through the pachytene stage of meiosis, and the formation of bivalent chromosomes at diakinesis. [WormBase] Observation: RNA interference in adulthood of skr-1 and skr-2 shortened the extended lifespan of daf-2(mu150) mutants by up to 44%. No effect in the lifespan of wild-type worms or in the extended lifespans of glp-1(e2141ts) or eat-2(ad1116) mutants was observed. Assays: Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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