Symbol: sgk-1 Name: Serum- and Glucocorticoid- inducible kinase homolog Entrez gene ID: 181697 Ensembl gene ID: W10G6.2 Species: Worm (Taxid: 6239) Functional description: SGK-1 acts in parallel to the AKT kinases to mediate DAF-2 signalling; Acts downstream of age-1 and pdk-1 in the daf-2/insulin receptor-like transduction pathway. Essential role in regulating development, stress response, and longevity. Phosphorylates Forkhead-related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their function. Acts downstream of rict-1 to regulate fat storage, size, and development. Does not appear to play a role in immune function. [UniProt] Observation: Inhibition of sgk-1 activity by RNAi results in an lifespan extension by approximately 60% which is suppressed by mutation of daf-16 [15068796]. Inactivation of sgk-1 either by mutation or RNAi results in animals that have severe a egg-laying defect, extended generation time, increased stress resistance, i.e. pleitropic phenotypes similar to mutants in daf-2, age-1, and pdk-1 [15068796]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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