Symbol: ry
Name: rosy
Entrez gene ID: 41605
Ensembl gene ID: FBgn0003308
Species: Fly
(Taxid: 7227)
Functional description:
Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid (By similarity). [UniProt]
Observation:
Loss-of-function mutation of ry reduces mean lifespan by 45% and maximum lifespan by 35% [17435236].
Interventions:
ry mutation
-45%
-35%
Assays:
Organismal Lifespan
Mean: -45
Maximum: -35
Classification:
Aging-Suppressor
Negative Aging-Suppressor
References:
17435236: Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles.
Aging Relevance Analysis/Source:
GenAge
GenDR
Homologs
XDH
(9606)
XDH
(9598)
XDH
(9615)
XDH
(9913)
Xdh
(10090)
Xdh
(10116)
XDH
(9031)
xdh
(7955)
ry
(7227)
AgaP_AGAP007918
(7165)
F55B11.1
(6239)
GeneID:5050113
(148305)
NCU03350
(5141)
XDH1
(3702)
XDH2
(3702)
Os03g0429800
(4530)
Inparanoids
FBpp0082172 (7227)
ENSMUSP00000024866 (10090)
ENSRNOP00000009634 (10116)
ENSMMUP00000036635 (9544)
ENSP00000368727 (9606)
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