Symbol: Plau Name: Plasminogen activator, urokinase Entrez gene ID: 18792 Ensembl gene ID: ENSMUSG00000021822 Species: Mouse (Taxid: 10090) Functional description: Specifically cleave the zymogen plasminogen to form the active enzyme plasmin. [UniProt] Observation: Transgenic mice (called alphaMUPA) overexpression Plau in many brain sites (including hypothalamus) consume (20%) less food, have a reduced body weight (by 20%) and length (by 6%), reduced temperature, and a prolonged lifespan (by 20%) [9060969]. alphaMUPA mice have reduced levels of blood sugar and smaller size and birth frequency compared to parental control [9060969] as well as a reduced body weight [10638529]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Inparanoids Edit \ Update (Admin) | Delete |
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