Symbol: pdk-1 Name: PDK-class protein kinase Entrez gene ID: 180475 Ensembl gene ID: H42K12.1 Species: Worm (Taxid: 6239) Functional description: Involved in the daf-2/insulin receptor-like transduction pathway, which controls longevity and prevents developmental arrest at the dauer stage. Phosphorylates and activates sgk-1, akt-1 and akt-2. [UniProt] Observation: Loss-of-function alleles in pdk-1 extend lifespan by 60% [10364160]. pdk-1(sa680) mutants are dauer constitutive (suppressed by daf-16) and a gain of function allele can suppress age-1 dauer constitutive phenotype [10364160]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Orthologs Edit \ Update (Admin) | Delete |
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