Symbol: nuc-1 Name: abnormal NUClease Entrez gene ID: 181174 Ensembl gene ID: C07B5.5 Species: Worm (Taxid: 6239) Functional description: Deoxyribonuclease II, involved in apoptotic DNA degradation [12718884]; Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Implicated in apoptosis. [UniProt] Observation: RNA interference of nuc-1 extends mean lifespan by 30%. nuc-1 is differentially transcribed in daf-16 and daf-2 RNAi animals [12845331]. nuc-1 null mutants display reduced fertility [11861554]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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