Symbol: mes-1 Name: Maternal Effect Sterile Entrez gene ID: 181362 Ensembl gene ID: F54F7.5 Species: Worm (Taxid: 6239) Functional description: Protein MES-1; Maternal Effect Sterile family member (mes-1) [Source:RefSeq peptide;Acc:NP_741906] [Ensembl]; The mes-1 gene encodes a receptor tyrosine kinase-like protein that is required for unequal cell divisions in the early embryonic germline; during embryonic cell divisions, mes-1 is involved in positioning of the early mitotic spindle and of associated P granules. [WormBase] Observation: mes-1(bn7) mutant animals that lack germ cells live about 60% longer than fertile mes-1(bn7) controls. This lifespan extension requires daf-16 [11799246]. Homozygous mes-1 mutant progeny from homozygous mutant mothers are sterile [1783292]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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