Symbol: let-60 Name: LEThal Entrez gene ID: 178104 Ensembl gene ID: ZK792.6 Species: Worm (Taxid: 6239) Functional description: The level of let-60 controls the switch between vulval and hypodermal cell fates during C.elegans vulval induction. [UniProt] Observation: The let-60(n1046gf) activating mutation greatly reduces lifespan of wild-type, weakly suppresses constitutive dauer diapause in daf-2 and age-1 mutants and extends lifespan induced by mutation of daf-2 [16164423]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Note: let-60 greatly decreases lifespan and appears not to have any epistatic interactions with daf-2. Edit \ Update (Admin) | Delete |
Comment on This Data Unit