Symbol: Irs1 Name: insulin receptor substrate 1 Entrez gene ID: 16367 Ensembl gene ID: ENSMUSG00000055980 Species: Mouse (Taxid: 10090) Functional description: Cytoplasmic signalling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines; May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). [UniProt] Observation: Median lifespan was extended 18% in knockouts from both sexes and 32% in females. Female animals displayed signs of resistance to ageing markers in skin, bone, immune system, and motor dysfunction, in spite of mild, lifelong insulin resistance. Heterozygous animals had normal lifespans. Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Orthologs Inparanoids Edit \ Update (Admin) | Delete |
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