Symbol: HXK2 Name: HeXoKinase 2 Alias: HEX1; SCI2; HKB Entrez gene ID: 852639 Ensembl gene ID: YGL253W Species: Yeast (Taxid: 4932) Functional description: Hxk2p; Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene [Source:SGD;Acc:S000003222] [Ensembl] Observation: Deletion of HXK2 extends mean and maximum replicative lifespan by about 53% and 33%, respectively. Limiting glucose availability by mutating HXK2 significantly extends replicative lifespan and provides a genetically model of DR [11000115]. HXK2 deletion increases oxygene consumption. Changes in gene expression HXK2 mutation are quite similar to those of dietary-restricted cells. In fact, HXK2 mutants have a transcriptional profile that significantly resembles DR cells and cell overexpressing HAP4 [12124627]. Interventions: Assays: Replicative Lifespan Mean: +53 Maximum: +33 Classification: Aging Relevance Analysis/Source: Homologs Orthologs Edit \ Update (Admin) | Delete |
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