Symbol: Trxr-1 Name: Thioredoxin reductase-1 Alias: GSR; Glutathione reductase Entrez gene ID: 31760 Ensembl gene ID: ZC395.6 Species: Fly (Taxid: 7227) Functional description: Redox regulation and oxidative defence; Thioredoxin system is a major player in glutathione metabolism, due to the demonstrated absence of a glutathione reductase. Functionally interacts with the Sod/Cat reactive oxidation species (ROS) defense system and thereby has a role in preadult development and life span. Lack of a glutathione reductase suggests antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms. [UniProt] Observation: Overexpression of Trxr-1 (alias GSR; glutathione reductase) in transgenic flies results in increased lifespan and oxidative stress resistance, but only under hyperoxia [10506576]. Interventions: Assays: Organismal Lifespan Classification: References: Aging Relevance Analysis/Source: Homologs Inparanoids Note: Wrong gene symbol in GenAge. Edit \ Update (Admin) | Delete |
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