Symbol: Ghrhr Name: Growth hormone releasing hormone receptor Entrez gene ID: 14602 Ensembl gene ID: ENSMUSG00000004654 Species: Mouse (Taxid: 10090) Functional description: Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion. [UniProt] Observation: Homozygosity for the Ghrhr(lit) knockout mutation (called little mouse) lowers plasma growth hormone levels, impairs growth and increases lonegevity about 20% [11371619]. Lit homozygous animals are smaller than normal mice [1270792] and their pituitary is defective in growth hormone and prolactin [978118]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Inparanoids Edit \ Update (Admin) | Delete |
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