Symbol: Zw
Name: Zwischenferment
Entrez gene ID: 32974
Ensembl gene ID: FBgn0004057
Species: Fly
(Taxid: 7227)
Observation:
Mean lifespan of G6PD overexpressor flies is extended in comparison with driver and responder controls, armadillo-GAL4 (up to 38%), Tubulin-GAL4 (up to 29%), C23-GAL4 (up to 27%), da-GAL4 (up to 24%), D42-GAL4 (up to 18%) and Appl-GAL4 (up to 16%). The maximum lifespan is also increased [18809674].
G6PD enzymatic activity as well as levels of NADPH, NADH, and the GSH/GSSG ration are increased [18809674].
Interventions:
Zw overexpression
+16 to + 38%
Assays:
Organismal Lifespan
Classification:
Aging-Suppressor
Positive Aging-Suppressor
Type:
Gene
Protein coding
References:
18809674: Overexpression of glucose-6-phosphate dehydrogenase extends the life span of Drosophila melanogaster.
Aging Relevance Analysis/Source:
GenAge
GenDR
Homologs
G6PD
(9606)
G6PD
(9615)
G6PD
(9913)
G6pdx
(10090)
G6pd
(10116)
wu:fj78b06
(7955)
LOC100148915
(7955)
Zw
(7227)
AgaP_AGAP010739
(7165)
AgaP_AGAP012678
(7165)
glucose-6-phosphate-1-dehydrogenase
(6239)
zwf1
(4896)
ZWF1
(4932)
KLLA0D19855g
(28985)
AGOS_ABL206C
(33169)
GeneID:2680896
(148305)
NCU09111
(5141)
G6PD5
(3702)
G6PD6
(3702)
Os04g0485300
(4530)
Os02g0600400
(4530)
PF14_0511
(5833)
Inparanoids
FBpp0074517 (7227)
ENSMUSP00000004327 (10090)
ENSRNOP00000053157 (10116)
ENSMMUP00000022920 (9544)
ENSP00000358633 (9606)
YNL241C (4932)
SPAC3A12.18 (4896)
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