Symbol: Jafrac1 Name: thioredoxin peroxidase 1 Entrez gene ID: 53578 Ensembl gene ID: FBgn0040309 Species: Fly (Taxid: 7227) Observation: Neuronal overexpression of Jafrac1 significantly increases both mean and maximum lifespan, while neuronal knockdown as well as loss of function mutation, causes a reduction in lifespan by 30%. The mean lifespan is 26% and 29% higher in females and males, respectively. The maximum lifespan is increased by 22% and 26% in females and males, respectively [19720829]. There is a consistent and significant lifespan extension (15% mean lifespan increase) in both males and females when Jafrac1 is overexpressed in somatic cells. Jafrac1 overexpression using the weaker 5961FS driver moderately but significantly extends lifespan [20976250]. Interventions: Assays: Organismal Lifespan Mean: +15 to +29 Maximum: +22 to +26 Classification: Type: References: Aging Relevance Analysis/Source: Homologs Inparanoids Edit \ Update (Admin) | Delete |
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