Symbol: Atg7 Name: Autophagy-specific gene 7 Entrez gene ID: 37141 Ensembl gene ID: FBgn0034366 Species: Fly (Taxid: 7227) Functional description: Involved in autophagy; Autophagy-specific gene 7; Autophagy-specific gene 7 [Source:FlyBase gene name;Acc:FBgn0034366] [Ensembl]; The gene Autophagy-specific gene 7 is referred to in FlyBase by the symbol Dmel\Atg7 (CG5489, FBgn0034366). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: catalytic activity; nucleotide binding. There is experimental evidence that it is involved in the biological process: determination of adult lifespan; macroautophagy; regulation of defense response to virus; regulation of autophagy; larval midgut cell programmed cell death. 11 alleles are reported. The phenotypes of these alleles are annotated with: rhabdomere; egg; adult brain. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: E1-like protein-activating enzyme Gsa7p/Apg7p; Molybdenum cofactor biosynthesis, MoeB; NAD(P)-binding domain; UBA/THIF-type NAD/FAD binding fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed during late larval stages, during early pupal stages. [FlyBase] Observation: Knockouts of Atg7 are short-lived with a 30% reduction in maximum lifespan and are hypersensitive to nutrient and oxidative stress [18056421; 19550147]. Interventions: Assays: Organismal Lifespan Maximum: -30 Classification: Aging Relevance Analysis/Source: Homologs Orthologs Inparanoids Note: GenAge reports a wrong study on mammalian which does not provide any data on Atg7 in fruit flies, right? Edit \ Update (Admin) | Delete |
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