Symbol: Dcr-2 Name: Dicer-2 Entrez gene ID: 36993 Ensembl gene ID: FBgn0034246 Species: Fly (Taxid: 7227) Function: Biogenesis of endogenous small interfering RNAs Observation: Median lifespan of homozyogous and transheterozyogous Dcr-2 mutants is reduced by 18-36% in males and by 27-36% in females. Dcr-2 loss changes the expression of mostly metabolic genes implicated in stress resistance and aging. Dcr-2 mutants are hypersensitive to oxidative, endoplasmic reticulum, starvation and cold stress as well as abnormal lipid and carbohydrate metabolism [21889502]. Interventions: Assays: Organismal Lifespan Mean: -18 to -36 Classification: References: Aging Relevance Analysis/Source: Homologs Inparanoids Edit \ Update (Admin) | Delete |
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