Symbol: tdp-1 Name: TAR DNA-binding Protein homolog 1 Alias: tag-169 Entrez gene ID: 174436 Ensembl gene ID: F44G4.4 Species: Worm (Taxid: 6239) Functional description: Protein TDP-1; Temporarily Assigned Gene name family member (tag-169) [Source:RefSeq peptide;Acc:NP_001022166] [Ensembl] Observation: tdp-1(ok803) mutation increases mean and maximum lifespan at 20 degree Celsius but not at 25 degree Celsius. tdp-1(ok803) reduce the lifespan of daf-2(e1370) mutants, but does not does not reduces the lifespan of daf-16(mu86) mutants. RNAi against tdp-1 reduces lifepsna of daf-2(e1370) mutants. tdp-1 overexpression strains have a reduced lifespan at 20 and 25 degree Celsius [Vaccaro et al. 2012]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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