Symbol: dod-18 Name: Downstream Of DAF-16 (regulated by DAF-16) Entrez gene ID: 183813 Ensembl gene ID: C54G4.6 Species: Worm (Taxid: 6239) Functional description: Protein DOD-18; Downstream Of DAF-16 (regulated by DAF-16) family member (dod-18) [Source:RefSeq peptide;Acc:NP_492205] [Ensembl]; dod-18 encodes a Maf-like protein required for normally short lifespan; dod-18 is repressed in daf-2 mutants and induced in daf-16 mutants, and dod-18(RNAi) lengthens lifespan by 30%; MAF-like proteins are ubiquitous among eukarya, bacteria, and archaea; DOD-18 is orthologous to the N-terminal ~200 residues of human ASMTL (OMIM:300162), and to Bacillus subtilis Maf (Multicopy Associated Filamentation) protein, which inhibits septum formation; while the specific biochemical function of Maf-like proteins is unknown, the tertiary structure of B. subtilis Maf is consistent with its binding nucleic acid. Other DOD-18 orthologs include budding yeast YOR111W, fission yeast SPAC3G6.03c, and Escherichia coli yhdE. [WormBase] Observation: RNA interference of dod-18 extends lifespan by 30%. dod-18 is differentially transcriped in daf-16 and daf-2 RNAi animals [12845331]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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