Symbol: UCHL1 Name: ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) Entrez gene ID: 7345 Ensembl gene ID: ENSG00000154277 Species: Human (Taxid: 9606) Functional description: Neuron-specific protease [2163617]; Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. [UniProt] Observation: UCHL1 is assoicated with Parkinson's disease [9774100]. UCHL1 belongs to a family of de-ubiquitinating enzymes responsible for the hydrolysis of bonds between ubiquitin molecules and small adducts [11084366]. Decreased activity due to mutation may result in decreased labeling of abnormal proteins for clearance. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Inparanoids Edit \ Update (Admin) | Delete |
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