Symbol: CDC7 Name: Cell Division Cycle 7 Alias: LSD6;SAS1 Entrez gene ID: 851545 Ensembl gene ID: YDL017W Species: Yeast (Taxid: 4932) Functional description: Cdc7p; DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression [Source:SGD;Acc:S000002175] [Ensembl]; DDK (Dbf4-dependent kinase) catalytic subunit required for origin firing and replication fork progression in mitotic S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression; required for pre-meiotic DNA replication, meiotic DSB formation, recruitment of the monopolin complex to kinetochores during meiosis I and as a gene-specific regulator of the meiosis-specific transcription factor Ndt80p [SGD] Observation: Transient inactivation of CDC7 results in a shortened replicative lifespan [2698814]. CDC7 participates in silencing and RAS2 modulates its activity [1990268]. Interventions: Assays: Replicative Lifespan Classification: References: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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