Symbol: ragc-1 Name: RAs-related GTP binding protein C homolog Entrez gene ID: 178084 Ensembl gene ID: Y24F12A.2 Species: Worm (Taxid: 6239) Functional description: Protein RAGC-1 Observation: ragc-1 RNAi only during adulthood increases mean, median and maximum lifespan by 13-33, 21 and 33-37% respectively, but failed so in skn-1 or daf-16 mutant (with and without FUdR). Interference with TORC1 by ragc-1 RNAi increases heat resistance in daf-16 and skn-1 mutants, but not not in skn-1;daf-16 double mutant. ragc-1 RNAi increases lifespan in a strain in which RNAi is restricted to the intestine (VP288). RNAi of ragc-1 decreases overall mRNA translation but increases autophagy (measured by LGG-1 puncta) [22560223]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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