Symbol: F43G9.5 Name: yeast Enhancer of DeCapping homolog Alias: hypothetical protein;WBGENE00009668 Entrez gene ID: 172657 Ensembl gene ID: F43G9.5 Species: Worm (Taxid: 6239) Functional description: Protein CFIM-1; Protein CFIM-1 [Source:UniProtKB/TrEMBL;Acc:Q93716] [Ensembl]; F43G9.5 encodes a NUDIX hydrolase that that inhibits DHC-1 in vivo, and is a (perhaps evolutionarily conserved) target of transcriptional activation by DAF-16; F43G9.5(RNAi) suppresses the lethality of conditional dhc-1 mutations, as well as the spindle length and cytokinesis defects of dhc-1(or195), indicating that F43G9.5 negatively regulates dynein; while loss of F43G9.5 function has no obvious effect on lifespan, dauer formation, or fat storage, F43G9.5 is required for embryonic development, fertility, and general health in mass RNAi assays. [WormBase] Observation: F43G9.5 RNAi in the adulthood extends the lifespan [New longevity regulators]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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