Symbol: vig-1 Name: VIG (Drosophila Vasa Intronic Gene) ortholog Alias: VIG (Drosophila Vasa Intronic Gene) ortholog family member (vig-1);WBGENE00006924 Entrez gene ID: 173512 Ensembl gene ID: F56D12.5 Species: Worm (Taxid: 6239) Functional description: Protein VIG-1; VIG (Drosophila Vasa Intronic Gene) ortholog family member (vig-1) [Source:RefSeq peptide;Acc:NP_740971] [Ensembl]; vig-1 encodes a predicted RNA-binding protein orthologous to Drosophila VIG (Vasa Intronic Gene); vig-1 activity is required for proper function of the let-7 miRNA in vivo and thus, for regulating the transition from late larval to adult cell fates; VIG-1 is a component of the 250 kDa RNA-induced silencing complex (RISC) complex and co-immunoprecipates with both TSN-1, the C. elegans Tudor-SN ortholog, and the let-7 miRNA. [WormBase] Observation: vig-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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