Symbol: hmg-4 Name: HMG 4 Alias: HMG family member (hmg-4);WBGENE00001974 Entrez gene ID: 176052 Ensembl gene ID: T20B12.8 Species: Worm (Taxid: 6239) Functional description: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Binds specifically to double-stranded DNA (By similarity). [UniProt] Observation: hmg-4 RNAi in the adulthood extends mean lifespan by 7%, without an effect on maximum lifespan [23144747]. Interventions: Assays: Organismal Lifespan Mean: +7 Maximum: 0 Classification: References: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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